GS-7340 Tenofovir alafenamide 379270-37-8

简要描述：GS-7340 Tenofovir alafenamide 379270-37-8
Tenofovir Alafenamide (GS-7340) is a prodrug of tenofovir, which is a reverse transcriptase inhibitor, used to treat HIV and Hepatitis B.

产品型号：abs47028038
厂商性质：生产厂家
更新时间：2026-01-14
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详细介绍

品牌	absin	CAS	379270-37-8
分子式	C21H29N6O5P	纯度	99%
分子量	476.47	货号	abs47028038
规格	2mg	供货周期	现货
主要用途	used to treat HIV and Hepatitis B.	应用领域	化工,生物产业,农林牧渔,制药/生物制药,综合

GS-7340 Tenofovir alafenamide 379270-37-8

产品描述
描述	Tenofovir Alafenamide (GS-7340) is a prodrug of tenofovir, which is a reverse transcriptase inhibitor, used to treat HIV and Hepatitis B.
纯度	99%
储存/保存方法	Store at -20℃ for one year（Powder）；Store at 2-4℃ for two weeks；Store at -20℃ for six months after dissolution.
基本信息
可溶性/溶解性	Soluble in DMSO
生物活性
靶点	Reverse transcriptase
In vitro(体外研究)	GS-7340 has a potent anti-HIV activity with IC50 of 0.005 μM. GS 7340 has a half-life of 90 min in human plasma and a half-life of 28.3 min in an MT-2 cell extract at 37°C. the hepatic uptake of GS-7340 isfacilitated by OATP1B1 and OATP1B3, respectively. GS-7340 inhibits HBV reverse transcriptase after being converted to the pharmacologically active form, TFV-DP.
In vivo(体内研究)	In male beagle dogs, GS 7340 (10 mg/kg, p.o.) results in an enhanced distribution to lymphatic tissue.
参考文献
参考文献	1. Chapman H, et al. Nucleosides Nucleotides Nucleic Acids. 2001, 20(4-7), 1085-10[90. 2. Lee WA, et al. Antimicrob Agents Chemother. 2005, 49(5), 1898-1906.

研究领域
研究领域	MetabolismTypes of disease Drug DiscoverySmall Molecule DrugLead Compound Discovery

GS-7340 Tenofovir alafenamide 379270-37-8温馨提示：本产品仅作科研实验使用，不支持临床等研究

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GS-7340 Tenofovir alafenamide 379270-37-8

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