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| 品牌 | absin | CAS | 850649-62-6 |
|---|---|---|---|
| 分子式 | C25H27N5O4 | 纯度 | 99% |
| 分子量 | 461.51 | 货号 | abs47028032 |
| 规格 | 5mg | 供货周期 | 现货 |
| 主要用途 | is a potent, selective inhibitor of DPP | 应用领域 | 化工,生物产业,农林牧渔,制药/生物制药,综合 |
Alogliptin Benzoate 850649-62-6
| 产品描述 | |
| 描述 | Alogliptin Benzoate(SYR 322) is a potent, selective inhibitor of DPP-4 with IC50 of <10 nM, exhibits greater than 10,000-fold selectivity over DPP-8 and DPP-9. |
| 纯度 | 99% |
| 储存/保存方法 | Store at -20℃ for one year（Powder）；Store at 2-4℃ for two weeks；Store at -20℃ for six months after dissolution. |
| 基本信息 | |
| 可溶性/溶解性 | 200 mM in DMSO |
| 生物活性 | |
| 靶点 | DPP-4 |
| In vitro(体外研究) | Alogliptin(SYR-322) is a potent inhibitor of DPP-4 and exhibits greater than 10,000 fold selectivity over the closely related serine proteases DPP-8 and DPP-9. Alogliptin is not an inhibitor of CYP-450 enzymes and does not block the hERG channel at concentrations up to 30 μM. |
| In vivo(体内研究) | Alogliptin(SYR-322) produces dose-dependent improvements in glucose tolerance and increases plasma insulin levels in female Wistar fatty rats. Acute administration of alogliptin results in a significant decrease in plasma DPP-4 activity, and increases plasma active GLP-1. Alogliptin improves glucose tolerance at a dose of 0.3 mg/kg and higher, with a dose-dependent increase in plasma IRI, suggesting that improved glucose tolerance results from the ability of alogliptin to enhance insulin secretion. |
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| 研究领域 | |
| 研究领域 | CancerCancer MetabolismResponse to hypoxia Proteolysis / UbiquitinProteolytic enzymesSerine proteaseDPPs ImmunologyAdaptive ImmunityB CellsCD ImmunologyAdaptive ImmunityT CellsCD ImmunologyCell Type MarkersCDAdhesion ImmunologyCell Type MarkersCDNon-lineage ImmunologyImmune System DiseasesAntiviral SignalingHIV-related MetabolismPathways and ProcessesMetabolism processesHypoxia MicrobiologyOrganismVirusDNA VirusssRNA positive strand virusSARS Coronavirus Stem CellsHematopoietic ProgenitorsLymphoidB Lymphocytic Lineage Stem CellsHematopoietic ProgenitorsLymphoidT Lymphocytic Lineage Drug DiscoverySmall Molecule DrugLead Compound Discovery |
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