Vipadenant 442908-10-3

Name: Vipadenant 442908-10-3abs47028016
Brand: absin
Price: 2229 CNY
Availability: InStock

简要描述：Vipadenant 442908-10-3
Vipadenant(BIIB-014) is an adenosine A2a antagonist with Ki of 1.3 nM; less potent for A1(Ki=69 nM).

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详细介绍

品牌	absin	CAS	442908-10-3
分子式	C16H15N7O	纯度	98%
分子量	321.34	货号	abs47028016
规格	1mg	供货周期	现货
主要用途	is an adenosine A2a antagonist	应用领域	化工,生物产业,农林牧渔,制药/生物制药,综合

Vipadenant 442908-10-3

产品描述
描述	Vipadenant(BIIB-014) is an adenosine A2a antagonist with Ki of 1.3 nM; less potent for A1(Ki=69 nM).
纯度	98%
储存/保存方法	Store at -20℃ for one year（Powder）；Store at 2-4℃ for two weeks；Store at -20℃ for six months after dissolution.
基本信息
可溶性/溶解性	10 mM in DMSO
生物活性
靶点	Adenosine Receptor
In vivo(体内研究)	Vipadenant (0.3-30 mg/kg) produces a dose-dependent reduction in catalepsy. Vipadenant (10 mg/kg) does not produce any statistically significant dyskinetic episodes in 6-OHDA-lesioned rats during a 19-day dosing regimen. In the mouse and rat haloperidol-induced hypolocomotion models, vipadenant has a minimum effective dose of 0.1 and 1 mg/kg, respectively. Vipadenant (3 and 10 mg/kg, p.o.) is able to increase contralateral rotations in 6-OHDA lesioned rats.
参考文献
参考文献	1. Brooks DJ, et al. Clin Neuropharmacol. 2010 Mar-Apr;33(2):55-60.

研究领域
研究领域	Drug DiscoverySmall Molecule DrugLead Compound Discovery

Vipadenant 442908-10-3温馨提示：本产品仅作科研实验使用，不支持临床等研究

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