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Product Category详细介绍
| 品牌 | absin | CAS | 937263-43-9 |
|---|---|---|---|
| 分子式 | C26H24N8O2 | 纯度 | 98% |
| 分子量 | 480.52 | 货号 | abs47028012 |
| 规格 | 10mg | 供货周期 | 现货 |
| 主要用途 | is a potent and selective HER2 inhibitor | 应用领域 | 化工,生物产业,农林牧渔,制药/生物制药,综合 |
Irbinitinib 937263-43-9
| 产品描述 | |
| 描述 | Irbinitinib(ARRY-380; ONT-380) is a potent and selective HER2 inhibitor with IC50 of 8 nM, equipotent against truncated p95-HER2, 500-fold more selective for HER2 versus EGFR. |
| 纯度 | 98% |
| 储存/保存方法 | Store at -20℃ for one year（Powder）；Store at 2-4℃ for two weeks；Store at -20℃ for six months after dissolution. |
| 基本信息 | |
| 可溶性/溶解性 | 10 mM in DMSO |
| 生物活性 | |
| 靶点 | p95 HER2 ,ErbB2 |
| In vitro(体外研究) | The compound is a reversible, ATP-competitive inhibitor with nanomolar potency against ErbB2 in both in vitro and in cell-based assays. Incell-based assays, ARRY-380 is ~500-fold selective for HER2 vs. EGFR and is equipotent against truncated p95-HER2. |
| In vivo(体内研究) | In vivo, ARRY-380 significantly inhibits tumor growth in multiple HER2-dependent tumor xenograft models. It shows excellent activity in numerous mouse tumor models including breast (BT-474, MDA-MB-453), ovarian (SKOV-3) and gastric (N87) carcinoma models. In the BT-474 model, ARRY-380 demonstrated significant dose-related tumor growth inhibition (TGI; 50% at 50 mg/kg/d and 96% at 100 mg/kg/d) with numerous partial regressions (>50% reduction from baseline size). |
| 参考文献 | |
| 参考文献 |
| 研究领域 | |
| 研究领域 | CancerTumor biomarkersOncoproteins CancerTumor immunologyTumor-associated antigens NeuroscienceDevelopment Signal TransductionProtein PhosphorylationTyrosine KinasesReceptor Tyrosine Kinases Tags & Cell MarkersCell Type MarkersTumor Associated Drug DiscoverySmall Molecule DrugLead Compound Discovery |
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