全国服务咨询热线：
18438616290
18438616290
产品分类
Product Category详细介绍
| 品牌 | absin | CAS | 1538604-68-0 |
|---|---|---|---|
| 分子式 | C26H22Cl2N4O3 | 纯度 | 98% |
| 分子量 | 509.38 | 货号 | abs47028005 |
| 规格 | 2mg | 供货周期 | 现货 |
| 主要用途 | is the first selective small molecule in | 应用领域 | 化工,生物产业,农林牧渔,制药/生物制药,综合 |
BLU9931 1538604-68-0
| 产品描述 | |
| 描述 | BLU9931 is the first selective small molecule inhibitor of FGFR4 with IC50 of 3 nM; less potent for FGFR1/2/3(IC50> 150 nM). |
| 纯度 | 98% |
| 储存/保存方法 | Store at -20℃ for one year（Powder）；Store at 2-4℃ for two weeks；Store at -20℃ for six months after dissolution. |
| 基本信息 | |
| 可溶性/溶解性 | 10 mM in DMSO |
| 生物活性 | |
| 靶点 | FGFR4 ,FGFR3 |
| In vitro(体外研究) | In MDA-MB-453 cells, BLU9931 potently inhibits phosphorylation of FGFR4 signaling pathway. BLU9931 inhibits proliferation of HCC cell lines that express an intact FGFR4 signaling complex, such as Hep 3B, HUH-7, and JHH-7 cell lines, with EC50 of |
| In vivo(体内研究) | In mice bearing the FGF19-amplified Hep 3B liver tumors, BLU9931 (300 mg/kg, p.o.) leads to tumor regression and prevents this weight loss induced by tumors. In mice bearing the FGF19-overexpressing PDX-derived LIXC012 xenografts, treatment with BLU9931 (300 mg/kg, p.o.) also leads to tumor regression. |
| 参考文献 | |
| 参考文献 |
|
| 研究领域 | |
| 研究领域 | CancerGrowth factorsFGF CardiovascularAngiogenesisGrowth FactorsFGFFGF Receptors MicrobiologyOrganismVirusDNA VirusssRNA positive strand virusSARS Coronavirus NeuroscienceDevelopment NeuroscienceCell Type MarkerNeural Stem Cell marker Signal TransductionGrowth Factors/HormonesFGF Stem CellsNeural Stem CellsSurface Molecules Drug DiscoverySmall Molecule DrugLead Compound Discovery |
产品咨询
地址：上海市浦东新区新浩路58号申江科创园18栋
邮箱：lanwu@univ-bio.com
传真：