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| 品牌 | absin | CAS | 111011-63-3 |
|---|---|---|---|
| 分子式 | C34H38N3O7P | 纯度 | 98% |
| 分子量 | 631.66 | 货号 | abs47027996 |
| 规格 | 10mg | 供货周期 | 现货 |
| 主要用途 | is a dual T-type and L-type calcium chan | 应用领域 | 化工,生物产业,农林牧渔,制药/生物制药,综合 |
Efonidipine 111011-63-3
| 产品描述 | |
| 描述 | Efonidipine(NZ-105) is a dual T-type and L-type calcium channel blocker (CCB). |
| 纯度 | 98% |
| 储存/保存方法 | Store at -20℃ for one year（Powder）；Store at 2-4℃ for two weeks；Store at -20℃ for six months after dissolution. |
| 基本信息 | |
| 别名 | 依福地平; NZ-105；(±)-Efonidipine |
| 可溶性/溶解性 | 10 mM in DMSO |
| 生物活性 | |
| 靶点 | T-type calcium channel |
| In vitro(体外研究) | Although efonidipine is not a specific T-type calcium channe (TTCC) blocker as it could also block L-type calcium channe (LTCC), its efficacy in blocking TTCC is much greater than that of LTCC. Efonidipine exerts an inhibitory effect on aldosterone synthesis and secretion in a human adrenocortical cell line (H295R), an effect that is mediated, at least in part, by suppression of 11-β-hydroxylase and aldosterone synthase expression. Efonidipine also suppresses both Ang II- and K+-induced aldosterone secretion, but it blocks the latter at much lower concentrations than the former. |
| In vivo(体内研究) | Efonidipine could provide broader beneficial effects including the heart, liver, and plasma, and antioxidant in iron-overload condition in both WT(muβ+⁄+) and HT(muβth-3 ⁄+,) mice. |
| 研究领域 | |
| 研究领域 | Cardiovascular Drug DiscoverySmall Molecule DrugLead Compound Discovery |
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