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简要描述：Acotiamide hydrochloride hydrate 773092-05-0Acotiamide Hydrochloride is the hydrochloride salt form of acotiamide, a prokinetic agent with gastrointestinal (GI) motility-enhancing activity.
产品型号：abs47027993厂商性质：生产厂家更新时间：2026-01-12访 问 量：596产品分类
Product Category详细介绍
| 品牌 | absin | CAS | 773092-05-0 |
|---|---|---|---|
| 分子式 | C21H37ClN4O8S | 纯度 | 98% |
| 分子量 | 541.06 | 货号 | abs47027993 |
| 规格 | 10mg | 供货周期 | 现货 |
| 主要用途 | is the hydrochloride salt form of acotia | 应用领域 | 化工,生物产业,农林牧渔,制药/生物制药,综合 |
Acotiamide hydrochloride hydrate 773092-05-0
| 产品描述 | |
| 描述 | Acotiamide Hydrochloride is the hydrochloride salt form of acotiamide, a prokinetic agent with gastrointestinal (GI) motility-enhancing activity. Although the exact mechanism by which acotiamide exerts its effect has yet to be fully elucidated, this agent appears to inhibit acetylcholinesterase (AchE), an enzyme responsible for the breakdown of acetylcholine (Ach). Increased Ach concentrations lead to an improvement of gastric emptying and GI motility and eventually to a reduction of dyspepsia symptoms. |
| 纯度 | 98% |
| 储存/保存方法 | Store at -20℃ for one year（Powder）；Store at 2-4℃ for two weeks；Store at -20℃ for six months after dissolution. |
| 基本信息 | |
| 别名 | 盐酸阿考替胺三水合物 |
| 可溶性/溶解性 | 10 mM in DMSO |
| 生物活性 | |
| In vitro(体外研究) | Acotiamide inhibits AChE with half maximal inhibitory concentrations (IC50) of 3.0, 2.3 and 1.2 μM for human recombinant, and rat and canine gastric AChEs, respectively. |
| In vivo(体内研究) | Acotiamide is concentrated into the stomach tissue by carrier-mediated uptake processes, which may account for the selective action of acotiamide for gastric smooth muscle but not for skeletal muscle and central nervous system in rats. |
| 参考文献 | |
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| 研究领域 | |
| 研究领域 | Immunology Metabolism Drug DiscoverySmall Molecule DrugLead Compound Discovery |
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