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| 品牌 | absin | CAS | 1037184-44-3 |
|---|---|---|---|
| 分子式 | C17H13Cl2NO4 | 纯度 | ≥98% |
| 分子量 | 366.2 | 货号 | abs47027972 |
| 规格 | 10mg | 供货周期 | 现货 |
| 主要用途 | is an inhibitor of RNA Helicase A (RHA) | 应用领域 | 化工,生物产业,农林牧渔,制药/生物制药,综合 |
YK-4-279 1037184-44-3
| 产品描述 | |
| 描述 | YK 4-279 is an inhibitor of RNA Helicase A (RHA) binding to the oncogenic transciption factor EWS-FLI1. YK-4-279 inhibits Ewing's sarcoma family tumor (ESFT) cell growth; YK-4-279 induces apoptosis. |
| 纯度 | ≥98% |
| 储存/保存方法 | Store at -20℃ for one year（Powder）；Store at 2-4℃ for two weeks；Store at -20℃ for six months after dissolution. |
| 基本信息 | |
| 别名 | YK 4-279 |
| 外观 | White or off white solid |
| 可溶性/溶解性 | DMSO : 25 mg/mL (68.27 mM) |
| 生物活性 | |
| 靶点 | RNA helicase A |
| In vitro(体外研究) | YK-4-279 eliminates cyclin D levels by blocking the interaction of EWS-FLI1 with RHA in EWS-FLI1-containing TC32 cells. YK-4-279 also specifically inhibits ESFT cell growth and induces apoptosis. YK-4-279 also inhibits ERG and ETV1 biological activity in fusion-positive prostate cancer cells, and further decreases cell motility and invasion. |
| In vivo(体内研究) | In vivo, YK-4-279 (1.5 mg/dose i.p.) inhibits the growth of ESFT xenograft tumors. In mouse model, YK-4-279 selectively prevents prostate cancer growth and metastasis in fusion-positive LNCaP-luc-M6 tumors. |
| 参考文献 | |
| 参考文献 |
| 研究领域 | |
| 研究领域 | CancerTumor biomarkers CancerTumor immunology Drug DiscoverySmall Molecule DrugLead Compound Discovery |
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