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Product Category详细介绍
| 品牌 | absin | CAS | 1052532-15-6 |
|---|---|---|---|
| 分子式 | C24H28Cl2N2O4 | 纯度 | ≥98% |
| 分子量 | 479.40 | 货号 | abs47027970 |
| 规格 | 10mg | 供货周期 | 现货 |
| 主要用途 | is a potent and selective PLK1 with IC50 | 应用领域 | 化工,生物产业,农林牧渔,制药/生物制药,综合 |
SBE13 Hydrochloride 1052532-15-6
| 产品描述 | |
| 描述 | SBE13 hydrochloride is a potent and selective PLK1 with IC50 of 0.2 nM; no inhibition om Aurora A kinase, Plk2 and Plk3. |
| 纯度 | ≥98% |
| 储存/保存方法 | Store at -20℃ for one year（Powder）；Store at 2-4℃ for two weeks；Store at -20℃ for six months after dissolution. |
| 基本信息 | |
| 别名 | SBE-13 HCl |
| 外观 | white to tan powder |
| 可溶性/溶解性 | DMSO : ≥ 100 mg/mL (208.59 mM) H2O : 5 mg/mL (10.43 mM; Need ultrasonic) |
| 生物活性 | |
| 靶点 | PLK1 |
| In vitro(体外研究) | SBE 13 decreases cell proliferation in various cancer cell lines, and causes a G2/M arrest followed by apoptosis. In primary cells, SBE 13 does not impair cell cycle and thus proliferation of primary cells. SBE13 in combination with Enzastaurin displays a synergistic reduction of cell proliferation and enhanced apoptosis induction in HCT116(p53-/-) cells. |
| 研究领域 | |
| 研究领域 | CancerCell cycleCell division Cell CycleCell DivisionSpindle Cell CycleKinases/PhosphatasesOther EpigeneticsCell cycleKinases/PhosphatasesOther NeuroscienceProcesses Drug DiscoverySmall Molecule DrugLead Compound Discovery |
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