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| 品牌 | absin | CAS | 5490-27-7 |
|---|---|---|---|
| 分子式 | C21H41N7O12.1.5H2SO4 | 纯度 | ＞98% |
| 分子量 | 730.71 | 货号 | abs47027949 |
| 规格 | 25mg | 供货周期 | 现货 |
| 主要用途 | is a semi-synthetic aminoglycoside antib | 应用领域 | 化工,生物产业,农林牧渔,制药/生物制药,综合 |
Dihydrostreptomycin sulfate 5490-27-7
| 产品描述 | |
| 描述 | Dihydrostreptomycin sulfate inhibits protein synthesis by binding to the 30S ribosomal subunit. Dihydrostreptomycin Sulfate is a semi-synthetic aminoglycoside antibiotic with bactericidal properties. This antibiotic is active against most gram-positive and gram-negative organisms and is used in the treatment of tuberculosis and tularemia. |
| 纯度 | ＞98% |
| 储存/保存方法 | Store at -20℃ for one year（Powder）；Store at 2-4℃ for two weeks；Store at -20℃ for six months after dissolution. |
| 基本信息 | |
| 别名 | 硫酸双氢链mei素；Dihydrostreptomycin sesquisulfate |
| 外观 | 白色或类白色结晶性粉末 |
| 可溶性/溶解性 | Water : 92 mg/mL (125.9 mM) |
| 生物活性 | |
| In vitro(体外研究) | The primary mechanism of action of the antibiotic dihydrostreptomycin is binding to and modifying the function of the bacterial ribosome, thus leading to decreased and aberrant translation of proteins. It enters bacterial cells by binding to a specific site on MscL(mechanosensitive channel of large conductance) and modifying its conformation, thus allowing the passage of K+ and glutamate out of, and dihydrostreptomycin into, the cell. |
| In vivo(体内研究) | Dihydrostreptomycin sulfate would cause cochlea damage in mouse model and cell proliferation in the spiral ligament may occur after the dihydrostreptomycin sulfate -induced damage. This process is probably related to the recovery of cochlear function. |
| 参考文献 | |
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| 研究领域 | |
| 研究领域 | MetabolismTypes of disease Drug DiscoverySmall Molecule DrugLead Compound Discovery |
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