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| 品牌 | absin | CAS | 206658-92-6 |
|---|---|---|---|
| 分子式 | C13H14N2.HCl.XH2O | 纯度 | ＞98% |
| 分子量 | 234.72 | 货号 | abs47027938 |
| 规格 | 50mg | 供货周期 | 现货 |
| 主要用途 | is an inhibitor of both acetyl | 应用领域 | 化工,生物产业,农林牧渔,制药/生物制药,综合 |
Tacrine hydrochloride hydrate 206658-92-6
| 产品描述 | |
| 描述 | Tacrine hydrochloride hydrate is an inhibitor of both acetyl (AChE) and butyryl-cholinestrase (BChE) with IC50s of 31 nM and 25.6 nM, respectively. |
| 纯度 | ＞98% |
| 储存/保存方法 | Store at -20℃ for one year（Powder）；Store at 2-4℃ for two weeks；Store at -20℃ for six months after dissolution. |
| 基本信息 | |
| 别名 | 他克林盐酸盐水合物 |
| 可溶性/溶解性 | DMSO : 32 mg/mL (126.61 mM; Need ultrasonic and warming) |
| 生物活性 | |
| 靶点 | AChE,BChE |
| In vitro(体外研究) | Tacrine hydrochloride hydrate (12.5 to 37.5 nM) inhibits venom acetylcholinesterase as well as human serum butyrylcholinesterase in a concentration-dependent manner. The IC50 is 31 nM for snake venom AChE and 25.6 nM for human BChE. |
| In vivo(体内研究) | Pretreatment with Tacrine hydrochloride hydrate also modifies absolute levels of cocaine self-administration during reacquisition. Body weight declines approximately one-half percent over four days of treatment with intravenous Tacrine hydrochloride hydrate. Delivery of Tacrine hydrochloride hydrate by osmotic pump does not alter either linear- or repeated- cocaine-induced locomotor activity. There is no significant main effect or interaction with Tacrine hydrochloride hydrate treatment on active lever responding during reinstatement. Post hoc comparisons indicate that rats self-administering cocaine has significantly lower alkaline phosphatase levels, relative to Tacrine hydrochloride hydrate- but not saline- treated rats evaluated by conditioned-place preference. |
| 参考文献 | |
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| 研究领域 | |
| 研究领域 | CardiovascularHeartCardiac arrhythmias NeuroscienceProcesses NeuroscienceNeurotransmitterAcetylcholine Drug DiscoverySmall Molecule DrugLead Compound Discovery |
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