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| 品牌 | absin | CAS | 826-39-1 |
|---|---|---|---|
| 分子式 | C11H22ClN | 纯度 | 98% |
| 分子量 | 203.75 | 货号 | abs47027913 |
| 规格 | 1mg | 供货周期 | 现货 |
| 主要用途 | is an orally active | 应用领域 | 化工,生物产业,农林牧渔,制药/生物制药,综合 |
Mecamylamine hydrochloride 826-39-1
| 产品描述 | |
| 描述 | Mecamylamine hydrochloride is an orally active, nonselective, noncompetitive nAChR antagonist that can treat various neuropsychiatric disorders. Mecamylamine hydrochloride is originally used as a ganglionic blocker in treating hypertension. Mecamylamine hydrochloride can easily crosses the blood-brain barrier. |
| 纯度 | 98% |
| 储存/保存方法 | Store at -20℃ for one year（Powder）；Store at 2-4℃ for two weeks；Store at -20℃ for six months after dissolution. |
| 基本信息 | |
| 别名 | 盐酸美加明 |
| 外观 | White crystalline powder |
| 可溶性/溶解性 | DMSO : 31.25 mg/mL (153.37 mM; Need ultrasonic) |
| 生物活性 | |
| 靶点 | nAChR |
| In vitro(体外研究) | Mecamylamine blocks muscle nAChRs in a use- and voltagedependent manner. Mecamylamine blocks the nicotinic currents via trapping mechanism. The main feature of this block is the phenomenon of block relief, which might be revealed by combined action of depolarization and activation of nAChRs. The experimental study of the Mecamylamine action on muscle nAChRs revealed that: (1) Mecamylamine (1-20 μM) reduces evoked end-plate currents (EPC) amplitude with Hill’s constant equal to 1.2 and IC50 = 7.8 μM at holding potential –70 mV; (2) the calculated depth of its interaction with the muscle nAChR channel is almost half of the one of neuronal nAChRs (0.37 compare to 0.72 for neuronal nAChRs); (3) simultaneous membrane depolarization and repetitive activation of postsynaptic nAChRs by motor nerve stimulation produced rapid block relief dependent on the degree of depolarization, number of conditioning signals and Mecamylamine concentration, and only slightly depended on the rate of stimulation. |
| In vivo(体内研究) | Mecamylamine (0.5-1 mg/kg; Intraperitoneal injection; C57BL/6J mice) has antidepressant-like effects in both the TST and FST and these effects are dependent on bothβ2 andα7 subunits. |
| 研究领域 | |
| 研究领域 | Cardiovascular Drug DiscoverySmall Molecule DrugLead Compound Discovery |
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