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| 品牌 | absin | CAS | 946518-60-1 |
|---|---|---|---|
| 分子式 | C24H32Cl4N6OS | 纯度 | 98% |
| 分子量 | 594.43 | 货号 | abs47027895 |
| 规格 | 2mg | 供货周期 | 现货 |
| 主要用途 | is a novel selective | 应用领域 | 化工,生物产业,农林牧渔,制药/生物制药,综合 |
LY2409881 triHCl 946518-60-1
| 产品描述 | |
| 描述 | LY2409881 trihydrochloride is a novel selective inhibitor of IKK2 with IC50 of 30 nM; IC50 for IKK1 and other common kinases is at least one log higher. |
| 纯度 | 98% |
| 储存/保存方法 | Store at -20℃ for one year（Powder）；Store at 2-4℃ for two weeks；Store at -20℃ for six months after dissolution. |
| 基本信息 | |
| 可溶性/溶解性 | 10 mM in DMSO |
| 生物活性 | |
| 靶点 | IKK2 |
| In vitro(体外研究) | LY2409881 inhibits constitutively activated NF-ƘB, and causes concentration- and time-dependent growth inhibition and apoptosis in diffuse large B-cell lymphoma (DLBCL) cells. In the ovarian cancer cell line SKOV3, LY2409881 demonstrates moderate cytotoxicity. LY2409881 is synergistic with doxorubicin and cyclophosphamide in SUDHL2 cell in inhibiting the cell growth, but not in LY1 cell. In both SUDHL2 and LY1 cells, LY2409881 is synergistic with the histone deacetylase (HDAC) inhibitor romidepsin in inhibiting the cell growth. |
| In vivo(体内研究) | In SCID-beige xenograft mouse model, LY2409881 (50, 100, and 200 mg/kg, i.p.) significantly inhibits the tumor growth. |
| 参考文献 | |
| 参考文献 |
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| 研究领域 | |
| 研究领域 | CancerCancer Metabolism CancerTumor biomarkers CancerTumor immunology Drug DiscoverySmall Molecule DrugLead Compound Discovery |
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