Bioymifi 1420071-30-2

简要描述：Bioymifi 1420071-30-2
Bioymifi can act as a single agent to induce DR5 clustering and aggregation, leading to apoptosis

产品咨询联系我们

产品分类

Product Category

查看全部

详细介绍

品牌	absin	CAS	1420071-30-2
分子式	C22H12BrN3O4S	纯度	98%
分子量	494.32	货号	abs47027888
规格	5mg	供货周期	现货
主要用途	can act as a single agent to induce DR5	应用领域	化工,生物产业,农林牧渔,制药/生物制药,综合

Bioymifi 1420071-30-2

产品描述
描述	Bioymifi can act as a single agent to induce DR5 clustering and aggregation, leading to apoptosis
纯度	98%
储存/保存方法	Store at -20℃ for one year（Powder）；Store at 2-4℃ for two weeks；Store at -20℃ for six months after dissolution.
基本信息
别名	DR5 Activator
外观	orange to dark orange red powder
可溶性/溶解性	DMSO : 12.5 mg/mL (25.29 mM; Need ultrasonic)
生物活性
靶点	DR5 receptor
In vitro(体外研究)	Bioymifi is able to promote cell death without the need for the Smac mimetic in T98G cells. At a 10 μM concentration, bioymifi induces processing of caspase-3 into smaller fragments. Caspase-8 and the related extrinsic apoptotic pathway are essential for bioymifi-induced cell death. Bioymifi induces DR5-dependent death pathways and is independent of TRAIL. Bioymifi binds the ECD of DR5 with a Kd of 1.2 μM but shows little binding affinity to the DR4 ECD. It has poor solubility in buffer solutions. Bioymifi promotes apoptosis by directly binding to and facilitating aggregation of DR5. When bioymifi reaches micromolar concentration, its capability to aggregate DR5 is strong enough to induce apoptosis in various cancer cells.
参考文献
参考文献

研究领域

CancerGrowth factorsTNF

CardiovascularAtherosclerosisVascular InflammationInflammatory mediators

ImmunologyInnate ImmunityCytokinesTNF Superfamily

MetabolismTypes of diseaseMetabolic disorders

MicrobiologyOrganismVirusDNA VirusssRNA positive strand virusSARS Coronavirus

NeuroscienceDevelopment

NeuroscienceDiseases

NeuroscienceProcesses

Signal TransductionGrowth Factors/HormonesTNF

Drug DiscoverySmall Molecule DrugLead Compound Discovery

Bioymifi 1420071-30-2温馨提示：本产品仅作科研实验使用，不支持临床等研究

产品咨询