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| 品牌 | absin | CAS | 65673-63-4 |
|---|---|---|---|
| 分子式 | C17H17BrN2O5 | 纯度 | ≥98% |
| 分子量 | 409.23 | 货号 | abs47027874 |
| 规格 | 50mg | 供货周期 | 现货 |
| 主要用途 | is a non-peptidic ligand of a Bcl-2 surf | 应用领域 | 化工,生物产业,农林牧渔,制药/生物制药,综合 |
HA14-1 65673-63-4
| 产品描述 | |
| 描述 | HA14-1 is a non-peptidic ligand of a Bcl-2 surface pocket with IC50 of ~9 μM. |
| 纯度 | ≥98% |
| 储存/保存方法 | Store at -20℃ for one year（Powder）；Store at 2-4℃ for two weeks；Store at -20℃ for six months after dissolution. |
| 基本信息 | |
| 别名 | HA 14-1 |
| 可溶性/溶解性 | DMSO : ≥ 50 mg/mL (122.18 mM) |
| 生物活性 | |
| 靶点 | Bcl-2 |
| In vitro(体外研究) | HA14-1 is a small molecule and nonpeptidic ligand of a Bcl-2 surface pocket with IC50 of approximately 9 μM. HA14-1 induces the apoptosis of HL-60 cells in a dose-dependent manner via caspase activation. HA14-1 shows cytotoxic effects on HF1A3, HF4.9 and HF28RA follicular lymphoma B cell lines with LC50 of 4.5 μM, 12.6 μM and 8.1 μM respectively. HA14-1 induces apoptosis of HF1A3, HF4.9 and HF28RA cells via caspase and ROS. |
| In vivo(体内研究) | HA14-1(400 nM) treatment did not have any significant effect on the growth of glioblastoma tumors in immunodeficient mice. But HA14-1 (400 nM) increases the effect of the DNA-damaging agent etoposide (2.5 mg/Kg) on glioblastoma growth in vivo. |
| 研究领域 | |
| 研究领域 | CancerCancer MetabolismCellular metabolic process CancerCancer MetabolismResponse to hypoxia CancerCell DeathApoptosisMetabolism CancerCell DeathApoptosisApoptosis MarkersBcl 2 family CancerInvasion/microenvironmentApoptosisBcl 2 family CancerOncoproteins/suppressorsOncoproteinsCell survival & death CancerTumor biomarkersOncoproteins ApoptosisIntracellularBcl2 Family MetabolismTypes of diseaseCancer MetabolismPathways and ProcessesMetabolism processesApoptosis MetabolismPathways and ProcessesMetabolism processesHypoxia MetabolismPathways and ProcessesMitochondrial MetabolismMitochondrial markers Signal TransductionMetabolismMitochondrial Drug DiscoverySmall Molecule DrugLead Compound Discovery |
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