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Product Category详细介绍
| 品牌 | absin | CAS | 564-25-0 |
|---|---|---|---|
| 分子式 | C22H24N2O8 | 纯度 | ≥98% |
| 分子量 | 444.44 | 货号 | abs47027821 |
| 规格 | 5mg | 供货周期 | 现货 |
| 主要用途 | is a synthetic tetracycline derivative | 应用领域 | 化工,生物产业,农林牧渔,制药/生物制药,综合 |
Doxycycline 564-25-0
| 产品描述 | |
| 描述 | Doxycycline is a synthetic tetracycline derivative with similar antimicrobial activity. |
| 纯度 | ≥98% |
| 储存/保存方法 | Store at -20℃ for one year（Powder）；Store at 2-4℃ for two weeks；Store at -20℃ for six months after dissolution. |
| 基本信息 | |
| 别名 | 多xi环素 |
| 外观 | Light yellow powder |
| 可溶性/溶解性 | Water:630 mg/L |
| 生物活性 | |
| In vitro(体外研究) | 100 ng/mL-5 µg/mL Dox can significantly alter the metabolic profile of the cell, as well as reduce the proliferative rate, though the effect size depends upon the particular cell line used. Doxycycline arrests cells in G1-S phase of the cell cycle in PANC-1 cells and induces the expression of p53 and its downstream target p21. It down-regulates antiapoptotic genes and induces proapoptotic genes. Doxycycline also induces apoptosis through a Fas/Fas-ligand dependent pathway in Jurkat T lymphocytes. |
| In vivo(体内研究) | Doxycycline successfully reduces tumor growth in vivo (inhibited pancreatic cancer cell growth). |
| 参考文献 | |
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| 研究领域 | |
| 研究领域 | CancerCancer Metabolism CancerTumor biomarkers CancerTumor immunology MetabolismTypes of disease Drug DiscoverySmall Molecule DrugLead Compound Discovery |
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