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| 品牌 | absin | CAS | 68302-57-8 |
|---|---|---|---|
| 分子式 | C15H14N2O4 | 纯度 | ＞98% |
| 分子量 | 298.29 | 货号 | abs47027799 |
| 规格 | 10mg | 供货周期 | 现货 |
| 主要用途 | is a specific inhibitor | 应用领域 | 化工,生物产业,农林牧渔,制药/生物制药,综合 |
Amlexanox 68302-57-8
| 产品描述 | |
| 描述 | Amlexanox (AA673; CHX3673) is a specific inhibitor of IKKε and TBK1; inhibition of IKKε and TBK1 activity as determined by MBP phosphorylation showing an IC50 of approximately 1–2 μM. |
| 纯度 | ＞98% |
| 储存/保存方法 | Store at -20℃ for one year（Powder）；Store at 2-4℃ for two weeks；Store at -20℃ for six months after dissolution. |
| 基本信息 | |
| 别名 | 氨lai呫诺;AA673；Amoxanox；CHX3673 |
| 外观 | white to beige powder |
| 可溶性/溶解性 | DMSO : 100 mg/mL（335.24 mM） |
| 生物活性 | |
| 靶点 | TBK1 ,IKK-ε |
| In vitro(体外研究) | Dose-response relationship of amlexanox inhibition of IKK-ɛ and TBK1 activity as determined by MBP phosphorylation showing an IC50 of approximately 1-2 μM. Amlexanox also blocks the activity of TBK1 at approximately the same concentrations but has no effect on IKK-α or IKK-β and at these concentrations do not block any other kinases from a broad panel representing most kinase families. Inhibition of IKK-ɛ or TBK1 by amlexanox is competitive for its substrate ATP, indicating that it interacts with the enzymes in the ATP-binding site. Amlexanox increases the phosphorylation of TBK1 at Ser172 in 3T3-L1 adipocytes and blocks polyinosinic:polycytidylic acid (poly I:C)-stimulated phosphorylation of interferon responsive factor-3 (IRF3), a presumed substrate of IKK-ɛ and TBK1. |
| In vivo(体内研究) | Treatment of obese mice with amlexanox elevates energy expenditure through increased thermogenesis, producing weight loss, improves insulin sensitivity and decreases steatosis. |
| 研究领域 | |
| 研究领域 | CancerOncoproteins/suppressorsOncoproteinsSignal transducers CancerSignal transductionProtein phosphorylationSerine/threonine kinasesOther EpigeneticsCell cycleKinases/PhosphatasesOther ImmunologyInnate ImmunityTLR Signaling Signal TransductionProtein PhosphorylationSer / Thr KinasesOther Kinases Drug DiscoverySmall Molecule DrugLead Compound Discovery |
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