全国服务咨询热线：
18438616290
18438616290
产品分类
Product Category详细介绍
| 品牌 | absin | CAS | 上海 |
|---|---|---|---|
| 分子式 | C20H28O2 | 纯度 | 98% |
| 分子量 | 300.44 | 货号 | abs47027783 |
| 规格 | 25mg | 供货周期 | 现货 |
| 主要用途 | used as a chemotherapy medication | 应用领域 | 化工,生物产业,农林牧渔,制药/生物制药,综合 |
Isotretinoin 4759-48-2
| 产品描述 | |
| 描述 | Isotretinoin(13-cis-Retinoic acid) is a medication used for the treatment of severe acne. It was first developed to be used as a chemotherapy medication for the treatment of brain cancer, pancreatic cancer and more. |
| 纯度 | 98% |
| 储存/保存方法 | Store at -20℃ for one year（Powder）；Store at 2-4℃ for two weeks；Store at -20℃ for six months after dissolution. |
| 基本信息 | |
| 别名 | 13-cis-Retinoic acid；异维Asuan；13-顺-视黄suan |
| 外观 | 黄色或者类橙色结晶性粉末 |
| 可溶性/溶解性 | DMSO : 60 mg/mL (199.7 mM) Ethanol : 1 mg/mL (3.32 mM), warmed |
| 生物活性 | |
| 靶点 | hydroxylase |
| In vitro(体外研究) | Isotretinoin directly interferes with the development of cranial neural crest cells. Isotretinoin selectively affects neural crest cells by decreasing their cell-substratum adhesion. |
| In vivo(体内研究) | Isotretinoin (500 ng/mL) and its main metabolite in the human, 4-oxo-isotretinoin, induce malformations similar to those seen in vivo. Isotretinoin impairs explicit memory in Stage 2, but retention tests one month after Isotretinoin exposure ended, indicated recovery from this explicit memory impairment and evidence of enhanced implicit memory in the 10 mg and 15 mg ISO rats. Isotretinoin slows the recovery of rod signaling after exposure to an intense bleaching light, and that rhodopsin regeneration is markedly slowed. Isotretinoin is also found to protect rat photoreceptors from light-induced damage. Isotretinoin blocks the formation of A2E biochemically and the accumulation of lipofuscin pigments by electron microscopy. Isotretinoin also blocks the slower, age-dependent accumulation of lipofuscin in wild-type mice. |
| 参考文献 | |
| 参考文献 |
|
| 研究领域 | |
| 研究领域 | Signal TransductionMetabolism Drug DiscoverySmall Molecule DrugLead Compound Discovery |
产品咨询
地址：上海市浦东新区新浩路58号申江科创园18栋
邮箱：lanwu@univ-bio.com
传真：