Vecuronium bromide 50700-72-6

简要描述：Vecuronium bromide 50700-72-6
Vecuronium (bromide) is a muscle relaxant in the category of non-depolarizing blocking agents.

产品咨询联系我们

产品分类

Product Category

查看全部

详细介绍

Vecuronium bromide 50700-72-6

产品描述
描述	Vecuronium (bromide) is a muscle relaxant in the category of non-depolarizing blocking agents.
纯度	＞98%
储存/保存方法	Store at -20℃ for one year（Powder）；Store at 2-4℃ for two weeks；Store at -20℃ for six months after dissolution.
基本信息
别名	维ku溴铵；ORG NC 45
外观	白色或类白色粉末
可溶性/溶解性	DMSO : 93 mg/mL (145.8 mM) Ethanol : 93 mg/mL (145.8 mM) Water : 4 mg/mL (6.27 mM)
生物活性
In vitro(体外研究)	Vecuronium inhibits both forms of the muscle-type acetylcholine receptor with IC50 of 1-2 mM. Vecuronium combined with methylprednisolone shows additive effects on both receptor forms, which is best described by a two-site model, with each site independent. Vecuronium interferes with nicotinic processes in the carotid body and inhibits the chemoreceptor neural response to hypoxia. Vecuronium significantly attenuates the increase in CSNA (DeltaCSNA) in response to hypoxia in the carotid body.
In vivo(体内研究)	Vecuronium (a monoquaternary ammonium compound) has a higher biliary clearance than pancuronium (a bisquaternary ammonium compound) in the rats.
参考文献
参考文献	1. Jonsson Fagerlund M, et al. Anesthesiology. 2009 Jun;110(6):1244-52. 2. Liu M, Dilger JP. Anesth Analg. 2008 Aug; 107(2):525-33. 3. Paul M, et al. Anesth Analg. 2002 Aug;95(2):362-7.

研究领域
研究领域	Neuroscience CancerTumor biomarkers Drug DiscoverySmall Molecule DrugLead Compound Discovery

Vecuronium bromide 50700-72-6温馨提示：本产品仅作科研实验使用，不支持临床等研究

产品咨询