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简要描述：Fesoterodine fumarate 286930-03-8Fesoterodine Fumarate is an antimuscarinic agent and is rapidly de-esterified to its active metabolite 5-hydroxymethyl tolterodine that is a muscarinic receptor antag
产品型号：abs47027716厂商性质：生产厂家更新时间：2025-12-25访 问 量：654产品分类
Product Category详细介绍
| 品牌 | absin | CAS | 286930-03-8 |
|---|---|---|---|
| 分子式 | C26H37NO3.C4H4O4 | 纯度 | ＞98% |
| 分子量 | 527.65 | 货号 | abs47027716 |
| 规格 | 10mg | 供货周期 | 现货 |
| 主要用途 | is an antimuscarinic agent | 应用领域 | 化工,生物产业,农林牧渔,制药/生物制药,综合 |
Fesoterodine fumarate 286930-03-8
| 产品描述 | |
| 描述 | Fesoterodine Fumarate is an antimuscarinic agent and is rapidly de-esterified to its active metabolite 5-hydroxymethyl tolterodine that is a muscarinic receptor antagonist. |
| 纯度 | ＞98% |
| 储存/保存方法 | Store at -20℃ for one year（Powder |
| 基本信息 | |
| 别名 | 富马酸非索罗定 |
| 外观 | 白色至类白色固体 |
| 可溶性/溶解性 | DMSO : 93 mg/mL (176.3 mM) Ethanol : 93 mg/mL (176.3 mM) Water : 92 mg/mL (174.4 mM) |
| 生物活性 | |
| 靶点 | AChR |
| In vitro(体外研究) | Fesoterodine is rapidly and extensively converted to 5-HMT, such that the pharmacologic activity appears to be primarily attributable to 5-HMT. Fesoterodine is a competitive antagonist of cholinergic agonist-stimulated responses in human M1-M5 cell lines and has a similar potency and selectivity profile to the radioligand-binding studies. Fesoterodine causes a rightward shift of the concentration-response curve for carbachol with no depression of the maximum in rat bladder strips, and concentration-dependently reduces contractions induced by electrical field stimulation (EFS). Fesoterodine is hydrolyzed by nonspecific esterases to 5-hydroxmethyl tolterodine (5-HMT), which is the active metabolite and is responsible for all its antimuscarinic activity. |
| 参考文献 | |
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| 研究领域 | |
| 研究领域 | Neuroscience Drug DiscoverySmall Molecule DrugLead Compound Discovery |
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