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| 品牌 | absin | CAS | 124858-35-1 |
|---|---|---|---|
| 分子式 | C19H21FN2O4 | 纯度 | 99% |
| 分子量 | 360.39 | 货号 | abs47027710 |
| 规格 | 25mg | 供货周期 | 现货 |
| 主要用途 | is a topical fluoroquinolone antibiotic | 应用领域 | 化工,生物产业,农林牧渔,制药/生物制药,综合 |
Nadifloxacin 124858-35-1
| 产品描述 | |
| 描述 | Nadifloxacin(OPC7251) is a topical fluoroquinolone antibiotic for the treatment of acne vulgaris. |
| 纯度 | 99% |
| 储存/保存方法 | Store at -20℃ for one year（Powder）；Store at 2-4℃ for two weeks；Store at -20℃ for six months after dissolution. |
| 基本信息 | |
| 别名 | 那氟sha星；OPC7251 |
| 外观 | 灰白色结晶固体 |
| 可溶性/溶解性 | DMSO : 16 mg/mL (44.4 mM) |
| 生物活性 | |
| In vitro(体外研究) | Nadifloxacin is a potent, broad-spectrum, quinolone agent approved for topical use in acne vulgaris and skin infections. Nadifloxacin inhibits the enzyme DNA gyrase that is involved in bacterial DNA synthesis and replication, thus inhibiting the bacterial multiplication. In vitro studies of nadifloxacin show potent and broad-spectrum antibacterial activity against aerobic Gram-positive, Gram-negative and anaerobic bacteria. Additionally, studies also suggest that the effectiveness of nadifloxacin in inflammatory acne lesions may be attributed to its inhibitory effect on pro-inflammatory cytokines like interleukin (IL)-1α, IL-6, and IL-8 which also play an important role in acne pathogenesis. |
| 参考文献 | |
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| 研究领域 | |
| 研究领域 | MetabolismTypes of disease Drug DiscoverySmall Molecule DrugLead Compound Discovery |
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