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| 品牌 | absin | CAS | 86386-73-4 |
|---|---|---|---|
| 分子式 | C13H12F2N6O | 纯度 | ＞98% |
| 分子量 | 306.27 | 货号 | abs47027676 |
| 规格 | 500mg | 供货周期 | 现货 |
| 主要用途 | used to treat oropharyngeal candidiasis | 应用领域 | 化工,生物产业,农林牧渔,制药/生物制药,综合 |
Fluconazole 86386-73-4
| 产品描述 | |
| 描述 | Triazole antifungal agent that is used to treat oropharyngeal candidiasis and cryptococcal meningitis in AIDS. |
| 纯度 | ＞98% |
| 储存/保存方法 | Store at -20℃ for one year（Powder）；Store at 2-4℃ for two weeks；Store at -20℃ for six months after dissolution. |
| 基本信息 | |
| 别名 | 氟kang唑; UK-49858 |
| 外观 | White to Off-White Solid |
| 可溶性/溶解性 | DMSO : ≥ 100 mg/mL (326.51 mM) |
| 生物活性 | |
| 靶点 | lanosterol 14 alpha-demethylase |
| In vitro(体外研究) | Fluconazole in combination with amphotericin B (AmB) has a synergistic effect on C. albicans planktonic cells but does not alter AmB activity against biofilms. Fluconazole and caspofungin have an antagonistic effect against biofilms but not with planktonic cells. Fluconazole-mediated membrane perturbation (due to inhibition of ergosterol biosynthesis) increases calcineurin inhibitor intracellular concentrations. Fluconazole treatment significantly reduces levels of ergosterol within the cell in C. albicans planktonic cells, leading to cell membrane perturbation. Fluconazole activity is less sensitive to acidic medium than is that of ketoconazole. Fluconazole is approximately 16-fold less active than ketoconazole against 35 representative isolates of C. albicans at physiologic pH. Fluvastatin, a cholesterol-lowering drug, exhibits minimal activity (MICs of 64 to >128 mg/mL) against Candida species and Cryptococcus neoformans. Fluconazole combined with itraconazole exhibits potent activities against C. albicans, C. tropicalis, C. parapsilosis, and C. neoformans, including flucon- azole-resistant strains of C. albicans and C. tropicalis. |
| In vivo(体内研究) | Fluconazole is very effective in prolonging survival of rats infected with a representative candidal strain. Fluconazole has a dramatic effect on the fungicidal activity of flucytosine in murine cryptococcal meningitis. Fluconazole combined with flucytosine and amphotericin B have significantly improved activity against cryptococcal meningitis compared with the activity of each drug used alone. |
| 研究领域 | |
| 研究领域 | CancerTumor immunology MetabolismTypes of disease Drug DiscoverySmall Molecule DrugLead Compound Discovery |
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