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| 品牌 | absin | CAS | 1210-83-9 |
|---|---|---|---|
| 分子式 | C12H14N2O2 | 纯度 | ＞98% |
| 分子量 | 218.25 | 货号 | abs47027650 |
| 规格 | 5mg | 供货周期 | 现货 |
| 主要用途 | is a naturally occurring chemical interm | 应用领域 | 化工,生物产业,农林牧渔,制药/生物制药,综合 |
N-Acetyl-5-hydroxytryptamine 1210-83-9
| 产品描述 | |
| 描述 | N-Acetylserotonin (NAS), also known as normelatonin, is a naturally occurring chemical intermediate in the endogenous production of melatonin from serotonin. It is produced from serotonin by the enzyme aralkylamine N-acetyltransferase |
| 纯度 | ＞98% |
| 储存/保存方法 | Store at -20℃ for one year（Powder）；Store at 2-4℃ for two weeks；Store at -20℃ for six months after dissolution. |
| 基本信息 | |
| 别名 | N-乙酰-5-羟色胺; N-Acetylserotonin；Normelatonin；O-Demethylmelatonin |
| 外观 | White to light brown powder |
| 可溶性/溶解性 | DMSO : 50 mg/mL (229.1 mM) Ethanol : 10 mg/mL (45.82 mM) |
| 生物活性 | |
| 靶点 | Sert (Sodium-dependent),TrkB |
| In vitro(体外研究) | N-Acetyl-5-hydroxytryptamine (NAS), a precursor of Melatonin, is acetylated from serotonin by AANAT (arylalkylamine N-acetyltransferase). N-acetylserotonin activates TrkB receptor in a circadian rhythm. N-Acetyl-5-hydroxytryptamine swiftly activates TrkB in a circadian manner and exhibits antidepressant effect in a TrkB-dependent manner. N-Acetyl-5-hydroxytryptamine rapidly activates TrkB, but not TrkA or TrkC, in a neurotrophin- and MT3 receptor-independent manner. |
| In vivo(体内研究) | To explore whether N-Acetyl-5-hydroxytryptamine, can trigger TrkB activation in vivo, TrkB F616A knockin mice are employed, where it has been shown that TrkB F616A activation can be selectively blocked by 1NMPP1, a derivative of kinase inhibitor PP1, leading to TrkB-null phenotypes. To assess whether N-Acetyl-5-hydroxytryptamine can mimic BDNF, cortical neurons from TrkB F616A knockin mice are prepared. In alignment with a previous report, BDNF- and NAS-mediated TrkB phosphorylation are selectively reduced by 1NMPP1 but not by K252a, whereas serotonin or Melatonin had no effect . These findings suggest that NAS strongly provokes both wild-type TrkB and TrkB F616A tyrosine phosphorylation and activation. |
| 参考文献 | |
| 参考文献 |
| 研究领域 | |
| 研究领域 | CancerOncoproteins/suppressorsOncoproteinsGrowth factor receptors Cell CycleCell differentiation Developmental BiologyOrganogenesisNervous system development MetabolismPathways and ProcessesMetabolism processesCellular metabolism NeuroscienceDevelopment NeuroscienceNeurology processNeurogenesis NeuroscienceNeurology processGrowth and DevelopmentNeurotrophins NeuroscienceNeurotransmissionIntracellular SignalingKinases Signal TransductionProtein PhosphorylationTyrosine KinasesReceptor Tyrosine Kinases Drug DiscoverySmall Molecule DrugLead Compound Discovery |
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