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| 品牌 | absin | CAS | 595-33-5 |
|---|---|---|---|
| 分子式 | C24H32O4 | 纯度 | ＞98% |
| 分子量 | 384.51 | 货号 | abs47027601 |
| 规格 | 50mg | 供货周期 | 现货 |
| 主要用途 | uses similar to those of the progestogen | 应用领域 | 化工,生物产业,农林牧渔,制药/生物制药,综合 |
Megestrol acetate 595-33-5
| 产品描述 | |
| 描述 | Megestrol acetate is a progestogen with actions and uses similar to those of the progestogens in general. Megestrol acetate also has anti-androgenic properties. It is given by mouth in the palliative treatment or as an adjunct to other therapy in endometrial carcinoma and in breast cancer. Megestrol acetate has been approved to treat anorexia and cachexia. |
| 纯度 | ＞98% |
| 储存/保存方法 | Store at -20℃ for one year（Powder）；Store at 2-4℃ for two weeks；Store at -20℃ for six months after dissolution. |
| 基本信息 | |
| 别名 | 醋酸jia地孕酮 |
| 外观 | White powder |
| 可溶性/溶解性 | DMSO : 20 mg/mL (52.01 mM; Need ultrasonic) |
| 生物活性 | |
| 靶点 | progestogen Receptor,Androgen Receptor |
| In vitro(体外研究) | Megestrol acetate inhibits the expression of cytoplasmic aromatase through nuclear C/EBPβ in reperfusion injury-induced ischemic rat hippocampus. Megestrol acetate significantly increases the proliferation, migration, and adipogenic differentiation of adipose-derived stem cells (ASCs) in a dose-dependent manner. Megestrol acetate also upregulates genes downstream of glucocorticoid receptor (GR) in ASCs. |
| In vivo(体内研究) | Megestrol acetate significantly decreases the circulating concentrations of estradiol (E2) and testosterone (T) in female fish or 11-ketotestosterone (11-KT) in male fish. Megestrol acetate exposure significantly downregulates the transcription of certain genes along the hypothalamic-pituitary-gonadal (HPG) axis. Megestrol acetate produces a progressive deterioration in glucose tolerance, with a significant increase in mean fasting plasma glucose concentrations and decrease in mean plasma glucose clearance rates after 6 months and 12 months of treatment in cats. Megestrol acetate also produces a progressive decrease in both resting plasma cortisol concentrations and cortisol concentrations after ACTH stimulation in cats. Megestrol acetate (50 mg/kg/day) for 9 days significantly increases food and water intake compared with untreated controls. Megestrol acetate (50 mg/kg/day) significantly (90-140%) increases in neuropeptide Y concentrations in the arcuate nucleus (where neuropeptide Y is synthesized), in the lateral hypothalamic rea (through which arcuate neurones project) and in the medial preoptic area, ventromedial nucleus and dorsomedial nucleus in rats. |
| 研究领域 | |
| 研究领域 | CancerSignal transductionNuclear signalingNuclear hormone receptorsOther Developmental BiologyReproductionHormones EpigeneticsNuclear Signaling PathwaysNuclear ReceptorsTestosterone NeuroscienceDevelopment NeuroscienceProcesses Signal TransductionSignaling PathwayNuclear SignalingNuclear Hormone ReceptorsTestosterone Drug DiscoverySmall Molecule DrugLead Compound Discovery |
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