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| 品牌 | absin | CAS | 797-63-7 |
|---|---|---|---|
| 分子式 | C21H28O2 | 纯度 | 99% |
| 分子量 | 312.45 | 货号 | abs47027592 |
| 规格 | 10mg | 供货周期 | 现货 |
| 主要用途 | is a Progestin and Progestin-containing | 应用领域 | 化工,生物产业,农林牧渔,制药/生物制药,综合 |
Levonorgestrel 797-63-7
| 产品描述 | |
| 描述 | Levonorgestrel is a Progestin and Progestin-containing Intrauterine Device. The physiologic effect of levonorgestrel is by means of Inhibit Ovum Fertilization. |
| 纯度 | 99% |
| 储存/保存方法 | Store at -20℃ for one year（Powder）；Store at 2-4℃ for two weeks；Store at -20℃ for six months after dissolution. |
| 基本信息 | |
| 别名 | 左炔诺yun酮 |
| 外观 | 白色或类白色结晶性粉末 |
| 可溶性/溶解性 | DMSO : 31.3 mg/mL (100 mM) |
| 生物活性 | |
| 靶点 | Progesterone receptor |
| In vitro(体外研究) | Levonorgestrel suppresses the stimulation of progesterone secretion induced by oLH, dibutyryl-cAMP and Pregnenolone in rats luteal cells. Levonorgestrel also inhibits constrictions evoked by either a high potassium (K(+)) solution or phorbol myristate acetate (PMA) in the absence and presence of extracellular calcium (Ca(2+)). Levonorgestrel depresses contractions evoked by Ca(2+) and reduces (45)Ca(2+) influx in depolarized veins. Levonorgestrel increases levels of cyclic AMP and inhibits PMA-induced activation of protein kinase C in veins. Levonorgestrel causes endothelium-independent relaxations of jugular veins via inhibition of Ca(2+) entry and of protein kinase Cactivation. Levonorgestrel inhibition of both estrogen-induced pituitary weight increment and hyperprolactinemia is reduced by mifepristone, whereas Flutamide is unable to block Levonorgestrel effects |
| In vivo(体内研究) | Levonorgestrel down-regulates the mRNA expression of follicle-stimulating hormone receptor (FSHR), luteinizing hormone receptor (LHR), estrogen receptor (ER) β and progesterone receptor (PR) in the ovary, and ERα and PR in the uterus of Mongolian gerbils. Levonorgestrel causes a significant upregulation of the mRNA expression of the gene encoding luteinising hormone β-subunit (lhβ) and the suppression of the mRNA expression of the gene encoding follicle-stimulating hormone β-subunit (fshβ) in the pituitary of both male and female roach. Levonorgestrel disrupts the reproductive system of pubertalroach by affecting the pituitary gonadotropin expression and the sex steroid levels in pubertal roach (Rutilus rutilus). |
| 参考文献 | |
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| 研究领域 | |
| 研究领域 | CancerSignal transductionNuclear signalingNuclear hormone receptorsProgesterone CancerTumor biomarkersReceptors EpigeneticsNuclear Signaling PathwaysNuclear ReceptorsProgesterone EpigeneticsTranscriptionDomain FamiliesZinc Finger NeuroscienceDevelopment NeuroscienceProcesses NeuroscienceEndocrine systemGonadotrophic axis Signal TransductionSignaling PathwayNuclear SignalingNuclear Hormone ReceptorsProgesterone Drug DiscoverySmall Molecule DrugLead Compound Discovery |
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