Triethylenethiophosphoramide 52-24-4

简要描述：Triethylenethiophosphoramide 52-24-4
Thiotepa is a polyfunctional, organophosphorus alkylating agent with antineoplastic activity.

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Triethylenethiophosphoramide 52-24-4

产品描述
描述	Thiotepa is a polyfunctional, organophosphorus alkylating agent with antineoplastic activity.
纯度	＞98%
储存/保存方法	Store at -20℃ for one year（Powder）；Store at 2-4℃ for two weeks；Store at -20℃ for six months after dissolution.
基本信息
别名	三亚乙基硫代磷酰胺；Thio-TEPA
外观	white solid
可溶性/溶解性	DMSO : 91 mg/mL (480.9 mM)
生物活性
靶点	DNA Alkylator_Crosslinker
In vitro(体外研究)	Thio-TEPA exhibits alkylating activity in rat liver slice incubation. Thio-TEPA does not affect the viability of rat liver slices, and is not accumulated in the slices at all doses of 2, 5, 10 mM.
In vivo(体内研究)	Thio-TEPA (20 mg/kg, i.p.) with total body irradiation (TBI) enhances donor-type blood chimerism during the first 10 weeks but is not dramatically higher than that of TBI group alone. Thio-TEPA alone improves both short- and long-term engraftment in mice.

研究领域
研究领域	CancerCancer Metabolism CancerTumor biomarkers CancerTumor immunology MetabolismTypes of disease Drug DiscoverySmall Molecule DrugLead Compound Discovery

Triethylenethiophosphoramide 52-24-4温馨提示：本产品仅作科研实验使用，不支持临床等研究

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