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| 品牌 | absin | CAS | 446-86-6 |
|---|---|---|---|
| 分子式 | C9H7N7O2S | 纯度 | ＞98% |
| 分子量 | 277.26 | 货号 | abs47027574 |
| 规格 | 50mg | 供货周期 | 现货 |
| 主要用途 | used in the treatment of organ transplan | 应用领域 | 化工,生物产业,农林牧渔,制药/生物制药,综合 |
Azathioprine 446-86-6
| 产品描述 | |
| 描述 | Azathioprine is an immunosuppressive drug, inhibiting purine synthesis and GTP-binding protein Rac1 activation, used in the treatment of organ transplantation and autoimmune diseases. |
| 纯度 | ＞98% |
| 储存/保存方法 | Store at -20℃ for one year（Powder）；Store at 2-4℃ for two weeks；Store at -20℃ for six months after dissolution. |
| 基本信息 | |
| 别名 | liu唑嘌呤；BW 57-322 |
| 外观 | 淡黄色粉末 |
| 可溶性/溶解性 | DMSO : 27.7 mg/mL (100 mM) |
| 生物活性 | |
| 靶点 | Rac1 |
| In vitro(体外研究) | Azathioprine suppresses the activation of Rac1 target genes such as mitogen-activated protein kinase kinase (MEK), NF-kappaB, and bcl-x(L), leading to a mitochondrial pathway of apoptosis in primary human CD4+ T lymphocytes. Azathioprine thus converts a costimulatory signal into an apoptotic signal by modulating Rac1 activity. Azathioprine-generated 6-Thio-GTP thus prevents the development of an effective immune response via blockade of Vav activity on Rac proteins. Azathioprine (1 mM) restores ATP levels and arrests cell injury, while culture in glucose-enriched media augments ATP levels and ameliorates cell death. Azathioprine reduces viability 5-34% at day 1 and 42-92% by day 4. Azathioprine decreases the viability of hepatocytes and induces the following events in primary culture of isolated rat hepatocytes: intracellular reduces glutathione (GSH) depletion, metabolic activity reduction, and lactate dehydrogenase release. Azathioprine effect on hepatocytes is associated with swelling and increased oxygen consumption of intact isolated rat liver mitochondria. |
| In vivo(体内研究) | Azathioprine combined with cyclosporin A and prednisolone has resulted in survival of 14 out of 15 grafts (93%), compared with 11 out of 14 (79%) in the group treated with cyclosporin A alone in mouse-rat brain xenograft. |
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| 研究领域 | |
| 研究领域 | CancerSignal transductionG protein signalingSmall G proteinsRas family ImmunologyInnate ImmunityTLR Signaling Signal TransductionSignaling PathwayG Protein SignalingSmall G ProteinsRas Family Drug DiscoverySmall Molecule DrugLead Compound Discovery |
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