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| 品牌 | absin | CAS | 75330-75-5 |
|---|---|---|---|
| 分子式 | C24H36O5 | 纯度 | ＞98% |
| 分子量 | 404.54 | 货号 | abs47027554 |
| 规格 | 5mg | 供货周期 | 现货 |
| 主要用途 | used for lowering cholesterol | 应用领域 | 化工,生物产业,农林牧渔,制药/生物制药,综合 |
Lovastatin 75330-75-5
| 产品描述 | |
| 描述 | Lovastatin is an HMG-CoA Reductase Inhibitor, used for lowering cholesterol. |
| 纯度 | ＞98% |
| 储存/保存方法 | Store at -20℃ for one year（Powder）；Store at 2-4℃ for two weeks；Store at -20℃ for six months after dissolution. |
| 基本信息 | |
| 别名 | 洛伐ta汀 |
| 外观 | White to off-white powder |
| 可溶性/溶解性 | Ethanol ：20.2 mg/mL (50 mM) DMSO ：40.5 mg/mL (100 mM) |
| 生物活性 | |
| 靶点 | HMG-CoA Reductase (HMGCR) |
| In vitro(体外研究) | Lovastatin is an inactive lactone prodrug that must be chemically or enzymatically converted to its dihydroxy open-acid form in order to elicit inhibitory activity. Lovastatin in its hydroxy acid form is an exceptionally potent competitive inhibitor of liver HMG CoA reductase. Lovastatin, other than its anticholesterol property, has diverse applications in the field of osteoporosis, neuro-degeneration, rheumatoid arthritis, antifungals and also is reported to reduce proliferation of lung cancer cells, breast cancer (MCF-7), liver cancer (HepG2). Lovastatin treatments show significant dose dependent cytotoxic effect on HeLa cells with IC50 value of 160 μg/mL. Lovastatin is effective to accelerate hydroxyl radical scavenging activity (54.06%) at an IC50 of 3601 μg/mL. |
| In vivo(体内研究) | Lovastatin is an inactive lactone that is hydrolyzed in the liver to an active f3-hydroxyacid form. This principal metabolite is the inhibitor of the enzyme HMG-CoA reductase. The Ki is 1 nM. Lovastatin and its β-hydroxyacid metabolite are highly bound to human plasma proteins. Lovastatin crosses the blood-brain and placental barriers. Lovastatin produces a profound reduction of apolipoprotein-B-containing lipoproteins, especially LDL cholesterol and, to a lesser extent, plasma triglycerides, and a small increase in HDL cholesterol. |
| 研究领域 | |
| 研究领域 | CancerCancer MetabolismMetabolic signaling pathwayMetabolism of lipids and lipoproteins CardiovascularAtherosclerosisLipoprotein metabolism CardiovascularLipids / LipoproteinsLipid MetabolismCholesterol Metabolism MetabolismTypes of diseaseHeart disease MetabolismPathways and ProcessesMetabolic signaling pathwaysLipid and lipoprotein metabolismCholesterol Metabolism MetabolismPathways and ProcessesMetabolic signaling pathwaysLipid and lipoprotein metabolismLipid metabolism MetabolismPathways and ProcessesMetabolic signaling pathwaysLipid and lipoprotein metabolismLipoprotein metabolism Signal TransductionMetabolismLipid metabolism Drug DiscoverySmall Molecule DrugLead Compound Discovery |
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