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| 品牌 | absin | CAS | 427-51-0 |
|---|---|---|---|
| 分子式 | C24H29ClO4 | 纯度 | 99% |
| 分子量 | 416.94 | 货号 | abs47027532 |
| 规格 | 50mg | 供货周期 | 现货 |
| 主要用途 | is the acetate salt of a synthetic ster | 应用领域 | 化工,生物产业,农林牧渔,制药/生物制药,综合 |
Cyproterone acetate 427-51-0
| 产品描述 | |
| 描述 | Cyproterone binds the androgen receptor (AR), thereby preventing androgen-induced receptor activation in target tissues and inhibiting the growth of testosterone-sensitive tumor cells. Cyproterone Acetate is the acetate salt of a synthetic steroidal antiandrogen with weak progestational and antineoplastic activities. This agent also exerts progestational agonist properties at the level of the pituitary that reduce luteinizing hormone (LH), resulting in reductions in testicular androgen secretion and serum testosterone levels. Treatment with cyproterone alone results in incomplete suppression of serum testosterone levels.Cyproterone binds the androgen receptor (AR), thereby preventing androgen-induced receptor activation in target tissues and inhibiting the growth of testosterone-sensitive tumor cells. Cyproterone Acetate is the acetate salt of a synthetic steroidal antiandrogen with weak progestational and antineoplastic activities. This agent also exerts progestational agonist properties at the level of the pituitary that reduce luteinizing hormone (LH), resulting in reductions in testicular androgen secretion and serum testosterone levels. Treatment with cyproterone alone results in incomplete suppression of serum testosterone levels. |
| 纯度 | 99% |
| 储存/保存方法 | Store at -20℃ for one year（Powder）；Store at 2-4℃ for two weeks；Store at -20℃ for six months after dissolution. |
| 基本信息 | |
| 别名 | 醋suan环丙孕酮 |
| 外观 | 白色粉末 |
| 可溶性/溶解性 | DMSO : 77 mg/mL (184.7 mM) Ethanol : 10 mg/mL (23.98 mM) |
| 生物活性 | |
| 靶点 | Androgen Receptor |
| In vitro(体外研究) | Cyproterone acetate clearly shows antagonistic properties, while being a partial agonist also, showing agonism for the AR, with EC50 of 4.0 μM, at relatively high concentrations. In the presence of 10 nM Testosterone, low concentrations of Cyproterone acetate inhibits T-stimulated transcription of 3XHRE-LUC, but at higher concentrations, transcription is stimulated. |
| In vivo(体内研究) | LH levels in Cyproterone acetate-treated rats do not dip below pretreatment levels, although they does not increase as much in the rats treated with 3.2 mg Cyproterone acetate/kg/day as in those which received 0.2 mg Cyproterone acetate/kg/day. Cyproterone acetate exhibits direct negative effect on reproductive organs weight and significant reducing effect on sperm count and Ca2+ contents. SOD and GST activities significantly decrease in addition to significant increase in NO, MDA contents reflecting the oxidative status of testis in Cyproterone acetate treated rats. Cyproterone acetate treatment plus artificial long days in autumn has a negative effect on sperm motility and sperm morphology. Androgen receptor occupation by Cyproterone acetate preferentially reduces the levels of spermatidal protamine in testis and spermatozoa involved in nuclear chromatin condensation. |
| 参考文献 | |
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| 研究领域 | |
| 研究领域 | CancerSignal transductionNuclear signalingNuclear hormone receptorsOther Developmental BiologyReproductionHormones EpigeneticsNuclear Signaling PathwaysNuclear ReceptorsTestosterone NeuroscienceDevelopment NeuroscienceProcesses Signal TransductionSignaling PathwayNuclear SignalingNuclear Hormone ReceptorsTestosterone Drug DiscoverySmall Molecule DrugLead Compound Discovery |
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