Mebendazole 31431-39-7

简要描述：Mebendazole 31431-39-7
Mebendazole is a highly effective, broad-spectrum antihelmintic indicated for the treatment of nematode infestations

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Mebendazole 31431-39-7

产品描述
描述	Mebendazole is a highly effective, broad-spectrum antihelmintic indicated for the treatment of nematode infestations; has been found as a hedgehog inhibitor.
纯度	＞98%
储存/保存方法	Store at -20℃ for one year（Powder）；Store at 2-4℃ for two weeks；Store at -20℃ for six months after dissolution.
基本信息
别名	jia苯咪唑
外观	白色至淡黄色结晶性粉末
可溶性/溶解性	DMSO : ≥ 23 mg/mL (77.89 mM)
生物活性
靶点	Parasite
In vitro(体外研究)	mebendazole (MZ), a derivative of benzimidazole, induces a dose- and time-dependent apoptotic response in human lung cancer cell lines. MZ arrests cells at the G2-M phase before the onset of apoptosis.MZ treatment also results in mitochondrial cytochrome c release, followed by apoptotic cell death. Additionally, MZ appears to be a potent inhibitor of tumor cell growth with little toxicity to normal WI38 and human umbilical vein endothelial cells.
In vivo(体内研究)	When administered p.o. to nu/nu mice, MZ strongly inhibits the growth of human tumor xenografts and significantly reduces the number and size of tumors in an experimental model of lung metastasis.MZ treatment significantly reduces vessel densities in mice compared with those in control mice.
参考文献
参考文献	1. Lubega GW, et al. Mol Biochem Parasitol. 1993 Dec;62(2):281-92. 2. MacDonald LM, et al. Mol Biochem Parasitol. 2004 Nov; 138(1):89-96. 3. Oxberry ME, et al. Parasitology. 2001 Jun; 122(Pt 6):683-7.

研究领域
研究领域	Stem CellsSignaling Pathways Drug DiscoverySmall Molecule DrugLead Compound Discovery

Mebendazole 31431-39-7温馨提示：本产品仅作科研实验使用，不支持临床等研究

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