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| 品牌 | absin | CAS | 73-78-9 |
|---|---|---|---|
| 分子式 | C14H22N2O·HCl | 纯度 | ＞98% |
| 分子量 | 270.8 | 货号 | abs47027519 |
| 规格 | 5g | 供货周期 | 现货 |
| 主要用途 | an amide local anesthetic | 应用领域 | 化工,生物产业,农林牧渔,制药/生物制药,综合 |
Lidocaine hydrochloride 73-78-9
| 产品描述 | |
| 描述 | Lidocaine HCl salt, an amide local anesthetic, has anti-inflammatory properties in vitro and in vivo, possibly due to an attenuation of pro-inflammatory cytokines, intracellular adhesion molecule-1 (ICAM-1), and reduction of neutrophils influx. |
| 纯度 | ＞98% |
| 储存/保存方法 | Store at -20℃ for one year（Powder）；Store at 2-4℃ for two weeks；Store at -20℃ for six months after dissolution. |
| 基本信息 | |
| 别名 | 盐酸利多ka因；Lignocaine hydrochloride |
| 外观 | 白色结晶性粉末 |
| 可溶性/溶解性 | DMSO : Soluble Ethanol : 54 mg/mL (199.41 mM) Water : ≥ 36 mg/mL (132.94 mM) |
| 生物活性 | |
| In vitro(体外研究) | Lidocaine above 1.25 g/l reduces cellular viability and triggers apoptosis in HCE cells in a time- and dose-dependent manner. Lidocaine-induced apoptosis is caspase dependent and may be related to mitochondrial pathway. Lidocaine, at the level of tissue concentration under topical or local administration, also has a direct inhibitory effect on the activity of epidermal growth factor receptor (EGFR), which is a potential target for antiproliferation in cancer cells. |
| In vivo(体内研究) | Intravenous administration of the local anaesthetic lidocaine has been used to treat neuropathic pain for several decades and significantly improves postoperative pain associated with complex spine surgery and cholecystectomy. It is well established that lidocaine used for regional anaesthesia blocks impulses in peripheral nerves by inhibiting voltage-gated sodium (Na+) channels. Intravenous lidocaine has an analgesic effect on mechanical noxious response, decreases the spinal noxious response induced by peripheral pinch stimuli and the frequency of spontaneous excitatory postsynaptic currents(EPSCs) without changing their amplitude. It has no effect on spontaneous inhibitory postsynaptic currents and produces an outward current in SG neurons. |
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| 研究领域 | |
| 研究领域 | Stem CellsSignaling Pathways Drug DiscoverySmall Molecule DrugLead Compound Discovery |
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