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Product Category详细介绍
| 品牌 | absin | CAS | 4342-03-4 |
|---|---|---|---|
| 分子式 | C6H10N6O | 纯度 | ＞98% |
| 分子量 | 182.18 | 货号 | abs47027506 |
| 规格 | 25mg | 供货周期 | 现货 |
| 主要用途 | used in the treatment of various cancers | 应用领域 | 化工,生物产业,农林牧渔,制药/生物制药,综合 |
Dacarbazine 4342-03-4
| 产品描述 | |
| 描述 | Dacarbazine(DTIC-Dome) is an antineoplastic chemotherapy drug used in the treatment of various cancers, among them malignant melanoma, Hodgkin lymphoma, sarcoma, and islet cell carcinoma of the pancreas. |
| 纯度 | ＞98% |
| 储存/保存方法 | Store at -20℃ for one year（Powder）；Store at 2-4℃ for two weeks；Store at -20℃ for six months after dissolution. |
| 基本信息 | |
| 别名 | 达ka巴嗪；Imidazole Carboxamide |
| 外观 | 微黄色结晶或粉末 |
| 可溶性/溶解性 | DMSO : 6.42 mg/mL (35.24 mM; Need ultrasonic and warming) |
| 生物活性 | |
| 靶点 | DNA polymerase beta |
| In vitro(体外研究) | Treatment of Dacarbazine sensitizes melanomas to lysis of peptide-specific CTL and it is is mediated through Fas-independent pathway. |
| In vivo(体内研究) | Treatment of combination of Axitinib and DTIC demonstrates significant antitumor activity against melanoma flank xenografts, reduces tumor cell proliferation and decreases the area of tumor necrosis and increases apoptosis. It also reduces meta-tasis-related factors and prolongs lifespan in mice. |
| 参考文献 | |
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| 研究领域 | |
| 研究领域 | CancerCancer Metabolism Drug DiscoverySmall Molecule DrugLead Compound Discovery |
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