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| 品牌 | absin | CAS | 108341-18-0 |
|---|---|---|---|
| 分子式 | C8H11NO3.C4H6O6.H2O | 纯度 | 99% |
| 分子量 | 337.28 | 货号 | abs47027473 |
| 规格 | 500mg | 供货周期 | 现货 |
| 主要用途 | is a direct alpha-adrenergic receptors s | 应用领域 | 化工,生物产业,农林牧渔,制药/生物制药,综合 |
Noradrenaline bitartrate monohydrate 108341-18-0
| 产品描述 | |
| 描述 | Noradrenaline bitartrate monohydrate is a direct alpha-adrenergic receptors stimulator. |
| 纯度 | 99% |
| 储存/保存方法 | Store at -20℃ for one year（Powder）；Store at 2-4℃ for two weeks；Store at -20℃ for six months after dissolution. |
| 基本信息 | |
| 别名 | 酒石酸去jia肾上腺素；Noradrenaline bitartrate monohydrate |
| 外观 | 白色或类白色结晶性粉末 |
| 可溶性/溶解性 | DMSO : 31.9 mg/mL (100 mM) water : 31.9 mg/mL (100 mM) |
| 生物活性 | |
| 靶点 | Adrenergic Receptor |
| In vitro(体外研究) | Norepinephrine(NE) bitartrate monohydrate is generally considered to be a β1-subtype selective adrenergic agonist. Norepinephrine(NE) also has direct activity at the β2-adrenoceptor in higher concentrations. Adipocytes from the inguinal fat pad (iWA) or the interscapular fat pad (BA) are isolated from neonatal wild-type C57BL/6J mice and cultured. To examine the effect of activating AT2 upon β-adrenergic signaling, cAMP production is first assessed in response to Norepinephrine (NE, 10 µM) with or without CGP (10 nM) co-treatment. Norepinephrine (NE) increases cAMP as expected in iWA, and CGP does not alter this effect. Norepinephrine (NE) is also known to induce lipolysis, and liberated fatty acids are required to functionally activate UCP1 protein and to stimulate heat production. CREB phosphorylation at Ser133 is increased after Norepinephrine (NE) treatment and significantly attenuated with CGP co-treatment in mouse iWA. |
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| 研究领域 | |
| 研究领域 | Cardiovascular NeuroscienceEndocrine system Drug DiscoverySmall Molecule DrugLead Compound Discovery |
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