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| 品牌 | absin | CAS | 26787-78-0 |
|---|---|---|---|
| 分子式 | C16H19N3O5S | 纯度 | ＞98% |
| 分子量 | 365.4 | 货号 | abs47027445 |
| 规格 | 10mg | 供货周期 | 现货 |
| 主要用途 | is the anhydrous | 应用领域 | 化工,生物产业,农林牧渔,制药/生物制药,综合 |
Amoxicillin 26787-78-0
| 产品描述 | |
| 描述 | Amoxicillin binds to and inactivates penicillin-binding proteins (PBPs) located on the inner membrane of the bacterial cell wall. Amoxicillin Anhydrous is the anhydrous form of a broad-spectrum, semisynthetic aminopenicillin antibiotic with bactericidal activity. Inactivation of PBPs interferes with the cross-linkage of peptidoglycan chains necessary for bacterial cell wall strength and rigidity. This interrupts bacterial cell wall synthesis and results in the weakening of the bacterial cell wall and causes cell lysis. |
| 纯度 | ＞98% |
| 储存/保存方法 | Store at -20℃ for one year（Powder）；Store at 2-4℃ for two weeks；Store at -20℃ for six months after dissolution. |
| 基本信息 | |
| 别名 | a莫西林；Amoxycillin |
| 外观 | 白色结晶性粉末 |
| 可溶性/溶解性 | DMSO : 68 mg/mL (186.1 mM) |
| 生物活性 | |
| In vitro(体外研究) | Amoxicillin treated cells secrete high amounts of interleukin-5 and mostly lower or no amounts of tumor necrosis factor alpha, interleukin-4, and interferon-gamma. Amoxicillin-specific T cell clones fails to show drug-specific cytotoxicity, but killed target cells in the presence of concanavalin A, indicating a principal ability to be cytolytic. Amoxicillin releases faster in pH 1.0 hydrochloric acid (HCl) than in pH 7.8 phosphate buffer. Amoxicillin would be degraded to some extent in a pH 1.0 HCl medium at 37 degrees C, which indicated that amoxicillin is not stable in an acidic surrounding. Amoxicillin inhibits 4 of 15 isolates at 8 mg/mL or less but is not bactericidal against any of the isolates at that concentration. Amoxicillin in combination with clavulanic acid is bactericidal for 14 of 15 isolates tested at an amoxicillin concentration of 4 mg/mL or less and a clavulanic acid concentration of 2 mg/mL or less. Amoxicillin inhibits 50% of isolates tested decreased from 0.5 mg/mL (range, 0.25 to 1 mg/mL) to 0.06 mg/mL (range, 0.01 to 0.25 mg/mL) in the presence of only 4 mg of cefotaxime per mL. |
| 参考文献 | |
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| 研究领域 | |
| 研究领域 | CancerTumor immunology MetabolismTypes of disease Drug DiscoverySmall Molecule DrugLead Compound Discovery |
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