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| 品牌 | absin | CAS | 58-28-6 |
|---|---|---|---|
| 分子式 | C18H23ClN2 | 纯度 | ＞98% |
| 分子量 | 302.84 | 货号 | abs47027434 |
| 规格 | 100mg | 供货周期 | 现货 |
| 主要用途 | is the hydrochloride salt | 应用领域 | 化工,生物产业,农林牧渔,制药/生物制药,综合 |
Desipramine hydrochloride 58-28-6
| 产品描述 | |
| 描述 | Desipramine Hydrochloride a secondary amine tricyclic antidepressant (TCA), is the hydrochloride salt form of desipramine. In the central nervous system (CNS), desipramine hydrochloride blocks the re-uptake of neurotransmitters, including norepinephrine and serotonin. This leads to an increase in the amount of these neurotransmitters in the synaptic cleft and prolongs their activities postsynaptically. |
| 纯度 | ＞98% |
| 储存/保存方法 | Store at -20℃ for one year（Powder）；Store at 2-4℃ for two weeks；Store at -20℃ for six months after dissolution. |
| 基本信息 | |
| 别名 | 盐酸去甲咪嗪 |
| 外观 | white to off-white powder |
| 可溶性/溶解性 | DMSO : 83.3 mg/mL (275.06 mM; Need ultrasonic and warming) |
| 生物活性 | |
| 靶点 | 5-HT Receptor |
| In vivo(体内研究) | Treatment of rats with Desipramine hydrochloride for 14 days reduces norepinephrine transporter (NET) expression in a dose-dependent manner, as indicated by a reduction of the specific binding of 3H-nisoxetine to the NET in preparations of cerebral cortex (F(3,16)=4.33, p(3,16)=4.34, p. |
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| 研究领域 | |
| 研究领域 | MetabolismTypes of diseaseObesity NeuroscienceProcesses NeuroscienceNeurology processMetabolism NeuroscienceNeurotransmissionReceptors / ChannelsGPCRSerotonin Receptors Signal TransductionSignaling PathwayG Protein SignalingGPCR Drug DiscoverySmall Molecule DrugLead Compound Discovery |
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