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| 品牌 | absin | CAS | 53003-10-4 |
|---|---|---|---|
| 分子式 | C42H70O11 | 纯度 | 98% |
| 分子量 | 751.01 | 货号 | abs47027380 |
| 规格 | 5mg | 供货周期 | 现货 |
| 主要用途 | a polyether ionophore antibiotic | 应用领域 | 化工,生物产业,农林牧渔,制药/生物制药,综合 |
Salinomycin 53003-10-4
| 产品描述 | |
| 描述 | Salinomycin, a polyether ionophore antibiotic isolated from Streptomyces albus, has been shown to kill CSCs in different types of human cancers, most likely by interfering with ABC drug transporters, the Wnt/β-catenin signaling pathway, and other CSC pathways |
| 纯度 | 98% |
| 储存/保存方法 | Store at -20℃ for one year（Powder）；Store at 2-4℃ for two weeks；Store at -20℃ for six months after dissolution. |
| 基本信息 | |
| 别名 | 盐霉素；沙利霉素; Procoxacin |
| 外观 | White to light yellow solid |
| 可溶性/溶解性 | DMSO : ≥ 36.7 mg/mL (48.87 mM) |
| 生物活性 | |
| 靶点 | Bacterial |
| In vitro(体外研究) | Salinomycin (Procoxacin) is an antibacterial and coccidiostat ionophore therapeutic agent. Salinomycin (Procoxacin) has been shown by Piyush Gupta to kill breast cancer stem cells at least 100 times more effectively than another popular anti-cancer compound (paclitaxel) in mice. The mechanism of action by which salinomycin (Procoxacin) kills cancer stem cells specifically remains unknown, but is thought to be due to its action as a potassium ionophore due to the detection of Nigericin in the same compound screen. Salinomycin has high toxicity and a narrow therapeutic window which may limit its clinical use. |
| In vivo(体内研究) | LD50: Mice 18mg/kg (i.p.), 50mg/kg (i.g.). |
| 研究领域 | |
| 研究领域 | CancerTumor biomarkers CancerTumor immunology Stem CellsCancer Stem Cells Drug DiscoverySmall Molecule DrugLead Compound Discovery |
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