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| 品牌 | absin | CAS | 18422-05-4 |
|---|---|---|---|
| 分子式 | C10H14N5O7P.H2O | 纯度 | ＞98% |
| 分子量 | 365.24 | 货号 | abs47027344 |
| 规格 | 10mg | 供货周期 | 现货 |
| 主要用途 | used as a monomer in RNA. | 应用领域 | 化工,生物产业,农林牧渔,制药/生物制药,综合 |
5'-AMP monohydrate 18422-05-4
| 产品描述 | |
| 描述 | Adenosine monophosphate (AMP), also known as 5'-adenylic acid, is a nucleotide that is used as a monomer in RNA. It is an ester of phosphoric acid and the nucleoside adenosine. AMP consists of a phosphate group, the sugar ribose, and the nucleobase adenine. As a substituent it takes the form of the prefix adenylyl-. |
| 纯度 | ＞98% |
| 储存/保存方法 | Store at -20℃ for one year（Powder）；Store at 2-4℃ for two weeks；Store at -20℃ for six months after dissolution. |
| 基本信息 | |
| 别名 | 腺苷-5'-单磷酸一水合物; Adenosine 5'-monophosphate monohydrate |
| 外观 | White to Off-White powder |
| 可溶性/溶解性 | H2O : 6.4 mg/mL (17.52 mM; Need ultrasonic) |
| 生物活性 | |
| 靶点 | Adenosine A1 receptor |
| In vitro(体外研究) | Adenosine 5'-monophosphate monohydrate is an adenosine A1 receptor agonist. Adenosine 5'-monophosphate monohydrate (5′-AMP)-induced cell toxicity is negligible at concentrations of 25 to 400 μM in RAW264.7 cells. Adenosine 5'-monophosphate monohydrate significantly attenuates the mRNA expression of tumor necrosis factor-α (TNF-α) and interleukin (IL)-6 in RAW264.7 cells. The dose-dependence of TNF-α and IL-6 mRNA show that at concentration of 400 μM, Adenosine 5'-monophosphate monohydrate exhibits the maximum inhibition. Exposure of cells to Adenosine 5'-monophosphate monohydrate significantly reduces recruitment of NF-κB p65 to TNF-α, IL-6, and IL-1β gene promoters. |
| In vivo(体内研究) | C57BL/6J mice treated with Adenosine 5'-monophosphate monohydrate (5′-AMP) markedly increases hepatic adenosine level. Survival rate in PBS-treated mice (n=15) is 60% (8 h) and 33.3% (24 h), whereas survival rate in Adenosine 5'-monophosphate monohydrate-treated mice (n=15) is 100% (8 h) and 93.3% (24 h). Serum aspartate transaminase (AST) and alanine transaminase (ALT) levels are significantly lowered in the Adenosine 5'-monophosphate monohydrate group than in the vehicle group. The area and extent of necrosis is attenuated and the infiltration of inflammatory cells is reduced in the Adenosine 5'-monophosphate monohydrate group. |
| 参考文献 | |
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| 研究领域 | |
| 研究领域 | Neuroscience Drug DiscoverySmall Molecule DrugLead Compound Discovery |
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