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| 品牌 | absin | CAS | 69-93-2 |
|---|---|---|---|
| 分子式 | C5H4N4O3 | 纯度 | 99% |
| 分子量 | 168.11 | 货号 | abs47027201 |
| 规格 | 100mg | 供货周期 | 现货 |
| 主要用途 | is the final oxidation | 应用领域 | 化工,生物产业,农林牧渔,制药/生物制药,综合 |
Uric Acid 69-93-2
| 产品描述 | |
| 描述 | An oxidation product, via XANTHINE OXIDASE, of oxypurines such as XANTHINE and HYPOXANTHINE. It is the final oxidation product of purine catabolism in humans and primates, whereas in most other mammals URATE OXIDASE further oxidizes it to ALLANTOIN. |
| 纯度 | 99% |
| 储存/保存方法 | Store at -20℃ for one year（Powder）；Store at 2-4℃ for two weeks；Store at -20℃ for six months after dissolution. |
| 基本信息 | |
| 别名 | 尿酸 |
| 外观 | 白色结晶 |
| 可溶性/溶解性 | 10 mM in DMSO |
| 生物活性 | |
| In vitro(体外研究) | Uric acid activates NFκB in a variety of cell culture models including proximal tubular cells. Uric acid suppresses 1-α hydroxylase mRNA and protein expression in dose dependent and time dependent manner. |
| In vivo(体内研究) | Uric acid is synthesized mainly in the liver, intestines and the vascular endothelium as the end product of an exogenous pool of purines, and endogenously from damaged, dying and dead cells, whereby nucleic acids, adenine and guanine, are degraded into uric acid. Uric acid is a strong reactive oxygen species (ROS) and peroxynitrite scavenger and antioxidant. Uric acid may exert fundamental roles in tissue healing via initiating the inflammatory process that is necessary for tissue repair, scavenging oxygen free radicals, and mobilizing progenitor endothelial cells. |
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| 研究领域 | |
| 研究领域 | Immunology Drug DiscoverySmall Molecule DrugLead Compound Discovery |
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