Nicotinamide-N-oxide 1986-81-8

简要描述：Nicotinamide-N-oxide 1986-81-8
Nicotinamide N-oxide is recognized as an in vivo metabolite of nicotinamide which is a precurser of nicotinamide-adenine dinucleotide (NAD+) in animals.

产品型号：abs47027193
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更新时间：2025-12-01
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详细介绍

品牌	absin	CAS	1986-81-8
分子式	C6H6N2O2	纯度	＞99%
分子量	138.12	货号	abs47027193
规格	50mg	供货周期	现货
主要用途	is recognized as an in vivo metabolite o	应用领域	化工,生物产业,农林牧渔,制药/生物制药,综合

Nicotinamide-N-oxide 1986-81-8

产品描述
描述	Nicotinamide N-oxide is recognized as an in vivo metabolite of nicotinamide which is a precurser of nicotinamide-adenine dinucleotide (NAD+) in animals. The enzyme that catalyzes the reduction of nicotinamide N-oxide to nicotinamide in the liver is xanthine oxidase.
纯度	＞99%
储存/保存方法	Store at -20℃ for one year（Powder）；Store at 2-4℃ for two weeks；Store at -20℃ for six months after dissolution.
基本信息
别名	N-氧代yan酰胺；烟碱-N-氧化物
外观	白色粉末
可溶性/溶解性	Limited solubility
生物活性
靶点	Drug Metabolite
In vitro(体外研究)	Nicotinamide is one of the forms of vitamin B3. It is a precursor for nicotinamide adenine dinucleotide, which is best known as an electron carrier in oxidative phosphorylation and as a cofactor for many dehydrogenases. It is metabolized through two enzymatic systems. The first system starts with the methylation of nicotinamide by nicotinamide N-methyltransferase, which can subsequently be oxidized by aldehyde oxidase. The second enzymatic system oxidizes nicotinamide to nicotinamide N-oxide. A series of nicotinamide N-oxides is synthesized and shown to be novel, potent, and selective antagonists of the CXCR2 receptor. Compound 1 has demonstrated potent inhibition of neutrophil chemotaxis (IC50=10 nM). Compound 2 is a selective antagonist of IL-8 binding (IC50=110 nM) and potent inhibitor of neutrophil chemotaxis (IC50=170 nM).
参考文献
参考文献	1. Tian YJ, et al. Br J Nutr. 2014 May;111(9):1594-601. 2. Maeta A, et al. Biosci Biotechnol Biochem. 2014;78(8):1306-9. 3. Li D, et al. Br J Nutr. 2013 Dec; 110(12):2156-64.

研究领域
研究领域	Cell CycleCell Division Signal TransductionSignaling PathwayG Protein SignalingGPCR MicrobiologyOrganismVirusRNA VirusssRNA positive strand virusSARS Coronavirus Drug DiscoverySmall Molecule DrugLead Compound Discovery

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Nicotinamide-N-oxide 1986-81-8

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