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| 品牌 | absin | CAS | 3963-95-9 |
|---|---|---|---|
| 分子式 | C22H23ClN2O8 | 纯度 | ＞98% |
| 分子量 | 478.88 | 货号 | abs47027107 |
| 规格 | 25mg | 供货周期 | 现货 |
| 主要用途 | used to treat various infections. | 应用领域 | 化工,生物产业,农林牧渔,制药/生物制药,综合 |
Methacycline hydrochlorid 3963-95-9
| 产品描述 | |
| 描述 | Methacycline hydrochloride is a tetracycline antibiotic, and also an inhibitor of epithelial–mesenchymal transition (EMT) with IC50 of roughly 5 μM, used to treat various infections. |
| 纯度 | ＞98% |
| 储存/保存方法 | Store at -20℃ for one year（Powder）；Store at 2-4℃ for two weeks；Store at -20℃ for six months after dissolution. |
| 基本信息 | |
| 别名 | 盐suan美他环素；盐酸甲烯tu霉素 |
| 外观 | 黄色结晶性粉末 |
| 可溶性/溶解性 | DMSO : 3 mg/mL (6.26 mM) Water : 5 mg/mL (10.44 mM) |
| 生物活性 | |
| 靶点 | protein synthesis |
| In vitro(体外研究) | Methacycline inhibits TGF-β1-induced α-smooth muscle actin, Snail1, and collagen I of primary alveolar epithelial cells. Methacycline inhibits TGF-β1-induced non-Smad pathways, including c-Jun N-terminal kinase, p38, and Akt activation, but not Smad or β-catenin transcriptional activity. Methacycline has no effect on baseline c-Jun N-terminal kinase, p38, or Akt activities or lung fibroblast responses to TGF-β1. |
| In vivo(体内研究) | Methacycline (100 mg/kg, i.p.) delivered daily beginning 10 days after intratracheal bleomycin improves survival at Day 17. Methacycline attenuates Bleomycin-induced canonical EMT markers, Snail1, Twist1, collagen I, as well as fibronectin protein and mRNA. Methacycline does not attenuate inflammatory cell accumulation or alter TGF-β1-responsive genes in alveolar macrophages. |
| 参考文献 | |
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| 研究领域 | |
| 研究领域 | MetabolismTypes of disease Drug DiscoverySmall Molecule DrugLead Compound Discovery |
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