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| 品牌 | absin | CAS | 13311-84-7 |
|---|---|---|---|
| 分子式 | C11H11F3N2O3 | 纯度 | ＞98% |
| 分子量 | 276.21 | 货号 | abs47027092 |
| 规格 | 50mg | 供货周期 | 现货 |
| 主要用途 | an antiandrogen drug | 应用领域 | 化工,生物产业,农林牧渔,制药/生物制药,综合 |
Flutamide 13311-84-7
| 产品描述 | |
| 描述 | Flutamide is an antiandrogen drug, with its active metablolite binding at androgen receptor. |
| 纯度 | ＞98% |
| 储存/保存方法 | Store at -20℃ for one year（Powder）；Store at 2-4℃ for two weeks；Store at -20℃ for six months after dissolution. |
| 基本信息 | |
| 别名 | 氟ta胺；SCH 13521 |
| 外观 | 淡黄色结晶性粉末 |
| 可溶性/溶解性 | DMSO : 51 mg/mL (184.6 mM) Ethanol : 51 mg/mL (184.6 mM) |
| 生物活性 | |
| 靶点 | Androgen Receptor |
| In vitro(体外研究) | Flutamide (Eulexin) is an antiandrogen drug. Flutamide-OH, the active metabolite of flutamide, directly binds at rat anterior pituitary androgen receptor with Ki values of 55 nM. Flutamide does not affect the proliferation of an androgen-sensitive clone of the mouse mammary carcinoma Shionogi SC-l 15 cells in culture, shows only antiandrogenic effect, but not androgenic effect. Flutamide provides treatment for prostate cancer when used along with leuprolide. |
| In vivo(体内研究) | Flutamide causes a markedly reduction in rat ventral prostate weight from 319 mg to 245 mg. A combination of flutamide and LHRH agonist induces an additive effect with a decrease in prostate weight to 101 mg, and an marked drop in prostatic ODC activity. |
| 参考文献 | |
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| 研究领域 | |
| 研究领域 | CancerSignal transductionNuclear signalingNuclear hormone receptorsOther Developmental BiologyReproductionHormones EpigeneticsNuclear Signaling PathwaysNuclear ReceptorsTestosterone NeuroscienceDevelopment NeuroscienceProcesses Signal TransductionSignaling PathwayNuclear SignalingNuclear Hormone ReceptorsTestosterone Drug DiscoverySmall Molecule DrugLead Compound Discovery |
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