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| 品牌 | absin | CAS | 31430-15-6 |
|---|---|---|---|
| 分子式 | C16H12FN3O3 | 纯度 | 99% |
| 分子量 | 313.29 | 货号 | abs816460 |
| 规格 | 10mg | 供货周期 | 现货 |
| 主要用途 | used to treat worm infection in humans | 应用领域 | 化工,生物产业,农林牧渔,制药/生物制药,综合 |
Flubendazole 31430-15-6
| 产品描述 | |
| 描述 | Flubendazole is an anthelmintic that is used to treat worm infection in humans. It is available OTC in Europe. |
| 纯度 | 99% |
| 储存/保存方法 | Store at -20℃ for one year（Powder）；Store at 2-4℃ for two weeks；Store at -20℃ for six months after dissolution. |
| 基本信息 | |
| 别名 | 氟苯咪唑 |
| 外观 | 白色固体 |
| 可溶性/溶解性 | DMSO : 3 mg/mL (9.58 mM) |
| 生物活性 | |
| 靶点 | Atg4B |
| In vitro(体外研究) | Flubendazole results in morphological changes included contraction of the soma region, formation of blebs on the tegument, rostellar disorganization, loss of hooks and destruction of microtriches in Echinococcus granulosus. Flubendazole have a bicyclic ring system in which a benzene has been fused to the -4 and -5 positions of the heterocycle (imidazole). Flubendazole and Albendazole shows similar potency in affecting rat embryonic development in vitro, inducing retardation of growth and dysmorphogenic effects at concentrations ≥0.5 μg/mL. |
| In vivo(体内研究) | Flubendazole (6.32 mg/kg/day) initially induces an arrest of embryonic development followed by a generalized cell death that leads to 100% embryolethality by gestation day (GD) 12.5. Flubendazole (3.46 mg/kg/day) markedly reduces embryonic development by GD 12.5 without causing cell death. Flubendazole in olive oil causes a statistically significant increase in embryolethality at doses of 7.83 mg/kg per day and higher, with complete resorption in all dams at 31.33 mg/kg per day in rats. Flubendazole treatment causes a slight increase of metyrapone and daunorubicin activities in hepatic as well as intestinal cytosol in birds. Flubendazole treatment leads to statistically significant inhibition of intestinal GST activity. Flubendazole treatment leads to slight but significant inhibition (decrease to 69%) of 7-ethoxyresorufin activity in hepatic microsomes. |
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| 研究领域 | |
| 研究领域 | CancerCell DeathAutophagyAPG gene products CancerCell DeathAutophagySignal Transduction CancerInvasion/microenvironmentECMExtracellular matrixOther CancerSignal transductionAutophagy CardiovascularHeartAutophagyAPG gene products Proteolysis / UbiquitinProteolytic enzymesOther proteases MetabolismPathways and ProcessesMetabolism processesAutophagy and mitophagy MetabolismPathways and ProcessesMetabolism processesAutophagy and mitophagyAPG gene products NeuroscienceProcesses Drug DiscoverySmall Molecule DrugLead Compound Discovery |
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