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Rabbit anti-Twist1 Polyclonal Antibody

简要描述:Rabbit anti-Twist1 Polyclonal Antibody Acts as a transcriptional regulator. Inhibits myogenesis by sequestrating E proteins, inhibiting trans-activation by MEF2, and inhibiting DNA-binding by MYOD1 th

  • 产品型号:abs131127
  • 厂商性质:生产厂家
  • 更新时间:2021-12-19
  • 访  问  量:19

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详细介绍

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应用领域化工,生物产业,能源
概述
描述
Rabbit anti-Twist1 Polyclonal Antibody Acts as a transcriptional regulator. Inhibits myogenesis by sequestrating E proteins, inhibiting trans-activation by MEF2, and inhibiting DNA-binding by MYOD1 through physical interaction. This interaction probably involves the basic domains of both proteins. Also represses expression of proinflammatory cytokines such as TNFA and IL1B. Regulates cranial suture patterning and fusion. Activates transcription as a heterodimer with E proteins. Regulates gene expression differentially, depending on dimer composition. Homodimers induce expression of FGFR2 and POSTN while heterodimers repress FGFR2 and POSTN expression and induce THBS1 expression. Heterodimerization is also required for osteoblast differentiation.
别名
Twist1抗体;ACS3; B-HLH DNA binding protein; bHLHa38; BPES2; BPES3; Class A basic helix-loop-helix protein 38; CRS; CRS1; CSO; H-twist; OTTHUMP00000116043; SCS; TWIST; Twist basic helix loop helix transcription factor 1; Twist family bHLH transcription factor 1; Twist homolog 1 (Drosophila); Twist homolog 1; TWIST homolog of drosophila; Twist related protein 1; Twist-related protein 1; TWIST1; TWST1_HUMAN;
宿主
Rabbit
特异性
The antibody detects endogenous levels of total Twist1 protein.
反应种属
Human;Mouse;Rat
应用
WB 1:500-1:2000, IHC 1:50-1:200, IF/ICC 1:100-1:500, ELISA(peptide) 1:20000-1:40000
免疫原
A synthesized peptide derived from Human TWIST1(Accession Q15672), corresponding to amino acid residues M1-P24.
性能
浓度
1mg/ml
纯化方法
The antiserum was purified by peptide affinity chromatography using SulfoLink™ Coupling Resin .
类型
Polyclonal Antibody
储存/保存方法
Store at -20 °C for one year. Avoid repeated freeze/thaw cycles
存储溶液
Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.Store at -20 °C.Stable for 12 months from date of receipt.
靶标
背景说明
Rabbit anti-Twist1 Polyclonal Antibody Acts as a transcriptional regulator. Inhibits myogenesis by sequestrating E proteins, inhibiting trans-activation by MEF2, and inhibiting DNA-binding by MYOD1 through physical interaction. This interaction probably involves the basic domains of both proteins. Also represses expression of proinflammatory cytokines such as TNFA and IL1B. Regulates cranial suture patterning and fusion. Activates transcription as a heterodimer with E proteins. Regulates gene expression differentially, depending on dimer composition. Homodimers induce expression of FGFR2 and POSTN while heterodimers repress FGFR2 and POSTN expression and induce THBS1 expression. Heterodimerization is also required for osteoblast differentiation. Represses the activity of the circadian transcriptional activator: NPAS2-ARNTL/BMAL1 heterodimer (By similarity).
组织特异性
Subset of mesodermal cells.
细胞定位
Nucleus;
UniProt
Q15672
实验结果图
Western blot analysis of extracts from JK, Raji and HL-60 cells using Twist1 Antibody
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