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Rabbit anti-TRPM2 Polyclonal Antibody

简要描述:Rabbit anti-TRPM2 Polyclonal Antibody TRPM2抗体;EREG 1; EREG1; Estrogen responsive element associated gene 1; Estrogen responsive element associated gene 1 protein; Estrogen-responsive element-associate

  • 产品型号:abs137019
  • 厂商性质:生产厂家
  • 更新时间:2022-10-18
  • 访  问  量:179

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详细介绍

品牌自营品牌供货周期现货
应用领域化工,生物产业,能源
概述
别名
Rabbit anti-TRPM2 Polyclonal Antibody TRPM2抗体;EREG 1; EREG1; Estrogen responsive element associated gene 1; Estrogen responsive element associated gene 1 protein; Estrogen-responsive element-associated gene 1 protein; KNP 3; KNP3; Long transient receptor potential channel 2; LTRPC 2; LTrpC-2; LTrpC2; MGC133383; NUDT9H; NUDT9L1; putative Ca2+ channel protein; putative Ca2+ channel protein; Transient receptor potential cation channel subfamily M member 2; Transient receptor potential channel 7; TRPC 7; TrpC7; TRPM 2; Trpm2; TRPM2_HUMAN;
宿主
Rabbit
特异性
TRPM2 Antibody detects endogenous levels of total TRPM2.
反应种属
Human;Mouse;Rat
预测反应种属
Bovine;Sheep;
应用
WB 1:1000-3000, IHC 1:200, ELISA(peptide) 1:20000-1:40000
免疫原
Rabbit anti-TRPM2 Polyclonal Antibody A synthesized peptide derived from Human TRPM2(Accession O94759), corresponding to amino acid residues N1416-E1441.
性能
浓度
1mg/ml
纯化方法
The antiserum was purified by peptide affinity chromatography using SulfoLink™ Coupling Resin .
类型
Polyclonal Antibody
储存/保存方法
Store at -20 °C for one year. Avoid repeated freeze/thaw cycles
存储溶液
Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.Store at -20 °C.Stable for 12 months from date of receipt.
靶标
背景说明
Isoform 1: Nonselective, voltage-independent cation channel that mediates Na+ and Ca2+ influx, leading to increased cytoplasmic Ca2+ levels (PubMed:11960981, PubMed:12594222, PubMed:11385575, PubMed:11509734, PubMed:11804595, PubMed:15561722, PubMed:16601673, PubMed:19171771, PubMed:20660597, PubMed:27383051, PubMed:27068538). Extracellular calcium passes through the channel and increases channel activity by binding to the cytoplasmic domain and stabilizing the channel in an open conformation (PubMed:19171771). Also contributes to Ca2+ release from intracellular stores in response to ADP-ribose (PubMed:19454650). Plays a role in numerous processes that involve signaling via intracellular Ca2+ levels (Probable). Besides, mediates the release of lysosomal Zn2+ stores in response to reactive oxygen species, leading to increased cytosolic Zn2+ levels (PubMed:25562606, PubMed:27068538). Activated by moderate heat (35 to 40 degrees Celsius) (PubMed:16601673). Activated by intracellular ADP-ribose, beta-NAD (NAD+) and similar compounds, and by oxidative stress caused by reactive oxygen or nitrogen species (PubMed:11960981, PubMed:11385575, PubMed:11509734, PubMed:11804595, PubMed:15561722, PubMed:16601673, PubMed:19171771, PubMed:27383051, PubMed:27068538). The precise physiological activators are under debate; the true, physiological activators may be ADP-ribose and ADP-ribose-2'-phosphate (PubMed:20650899, PubMed:25918360). Activation by ADP-ribose and beta-NAD is strongly increased by moderate heat (35 to 40 degrees Celsius) (PubMed:16601673). Likewise, reactive oxygen species lower the threshold for activation by moderate heat (37 degrees Celsius) (PubMed:22493272). Plays a role in mediating behavorial and physiological responses to moderate heat and thereby contributes to body temperature homeostasis. Plays a role in insulin secretion, a process that requires increased cytoplasmic Ca2+ levels (By similarity). Required for normal IFNG and cytokine secretion and normal innate immune immunity in response to bacterial infection. Required for normal phagocytosis and cytokine release by macrophages exposed to zymosan (in vitro). Plays a role in dendritic cell differentiation and maturation, and in dendritic cell chemotaxis via its role in regulating cytoplasmic Ca2+ levels (By similarity). Plays a role in the regulation of the reorganization of the actin cytoskeleton and filopodia formation in response to reactive oxygen species via its role in increasing cytoplasmic Ca2+ and Zn2+ levels (PubMed:27068538). Confers susceptibility to cell death following oxidative stress (PubMed:12594222, PubMed:25562606).
组织特异性
Highly expressed in brain and peripheral blood cells, such as neutrophils. Also detected in bone marrow, spleen, heart, liver and lung. Isoform 2 is found in neutrophil granulocytes.
细胞定位
Lysosome;Plasma Membrane;
UniProt
O94759
实验结果图
Western blot analysis TRPM2 using K562 whole cell lysates
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