概述 |
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描述 | This antigen is associated with early stages of melanoma tumor progression. May play a role in growth regulation |
别名 | CD63抗体;Lysosomal associated membrane protein 3; CD 63; CD63; CD63 antigen (melanoma 1 antigen); CD63 antigen; CD63 antigen melanoma 1 antigen; CD63 molecule; CD63_HUMAN; gp55; Granulophysin; LAMP 3; LAMP-3; LAMP3; LIMP; Lysosomal-associated membrane protein 3; Lysosome associated membrane glycoprotein 3; Mast cell antigen AD1; ME491; Melanoma 1 antigen; Melanoma associated antigen ME491; Melanoma associated antigen MLA1; Melanoma-associated antigen ME491; MGC72893; MLA 1; MLA1; NGA; Ocular melanoma associated antigen; Ocular melanoma-associated antigen; OMA81H; PTLGP40; Tetraspanin 30; Tetraspanin-30; Tspan 30; Tspan-30; TSPAN30; |
宿主 | Rabbit anti-CD63 Polyclonal Antibody Rabbit |
特异性 | CD63 antibody detects endogenous levels of total CD63. |
反应种属 | Human;Mouse;Rat |
应用 | WB 1:500-1:2000, IHC 1:50-1:200, IF 1:100-1:500, ELISA(peptide) 1:20000-1:40000 |
免疫原 | A synthesized peptide derived from Human CD63(Accession P08962), corresponding to amino acid residues A148-T174. |
性能 |
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浓度 | Rabbit anti-CD63 Polyclonal Antibody 1mg/ml |
纯化方法 | The antiserum was purified by peptide affinity chromatography using SulfoLink™ Coupling Resin . |
类型 | Polyclonal Antibody |
储存/保存方法 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles |
存储溶液 | Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
靶标 |
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背景说明 | Functions as cell surface receptor for TIMP1 and plays a role in the activation of cellular signaling cascades. Plays a role in the activation of ITGB1 and integrin signaling, leading to the activation of AKT, FAK/PTK2 and MAP kinases. Promotes cell survival, reorganization of the actin cytoskeleton, cell adhesion, spreading and migration, via its role in the activation of AKT and FAK/PTK2. Plays a role in VEGFA signaling via its role in regulating the internalization of KDR/VEGFR2. Plays a role in intracellular vesicular transport processes, and is required for normal trafficking of the PMEL luminal domain that is essential for the development and maturation of melanocytes. Plays a role in the adhesion of leukocytes onto endothelial cells via its role in the regulation of SELP trafficking. May play a role in mast cell degranulation in response to Ms4a2/FceRI stimulation, but not in mast cell degranulation in response to other stimuli. |
组织特异性 | Detected in platelets (at protein level). Dysplastic nevi, radial growth phase primary melanomas, hematopoietic cells, tissue macrophages. |
翻译后修饰 | Palmitoylated at a low, basal level in unstimulated platelets. The level of palmitoylation increases when platelets are activated by thrombin (in vitro). |
细胞定位 | Endosome;Extracellular region or secreted;Lysosome;Plasma Membrane; |
UniProt | P08962 |
实验结果图 |
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| Western blot analysis of CD63 expression in Human platelet lysate;The lane on the left is treated with the antigen-specific peptide. |
温馨提示:本产品仅作科研实验使用,不支持临床等研究 |
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