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Rabbit anti-CD278/ICOS Recombinant Monoclonal Anti

简要描述:Rabbit anti-CD278/ICOS Recombinant Monoclonal Antibody(R104),储存溶液:PBS, 40% Glycerol, 0.05% BSA, 0.03% Proclin 300

  • 产品型号:abs171777
  • 厂商性质:生产厂家
  • 更新时间:2024-03-03
  • 访  问  量:798

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详细介绍

品牌absinCAS-
分子式-纯度-
分子量-货号abs171777
规格100uL供货周期现货
主要用途IHC-P: 1:500应用领域化工,生物产业,综合
概述
别名
Inducible T-cell costimulator; AILIM
宿主
Rabbit
反应种属
Human
应用
IHC-P: 1:500
性能
形式
Liquid
浓度
0.5 mg/ml
纯化方法
Protein A affinity column
类型
Monoclonal Antibody
克隆号
R104
储存/保存方法
Store at -20℃ for one year.
存储溶液
PBS, 40% Glycerol, 0.05% BSA, 0.03% Proclin 300
靶标
背景说明
Inducible T cell costimulatory factor (ICOS, cluster of differentiation, CD278) is an activated costimulatory immune checkpoint expressed on T cells. Its ligand ICOSL was expressed in antigen-presenting cells and somatic cells (including tumor cells in the tumor microenvironment) [PMID: 28713380, PMID: 12800259]. As one of the most common targeted immune checkpoints, ICOS is considered a possible way to develop new immunotherapy [PMID: 29544515]. Some clinical studies shown that blocking ICOS alone can inhibit tumor growth and proliferation, as well as TIGIT, CTLA4, and PD-1 [PMID: 30232519, PMID: 28803728].
细胞定位
Cell Membrane, Secreted
UniProt
Q9Y6W8
实验结果图
IHC shows positive staining in paraffin-embedded human thymus. Anti-CD278/ICOS antibody was used at 1/500 dilution, Secondary antibody: #abs20040. Counterstained with hematoxylin. Heat mediated antigen retrieval with Tris/EDTA buffer pH9.0 was performed before commencing with IHC staining protocol.
IHC shows positive staining in paraffin-embedded human tonsil. Anti-CD278/ICOS antibody was used at 1/500 dilution, Secondary antibody: #abs20040. Counterstained with hematoxylin. Heat mediated antigen retrieval with Tris/EDTA buffer pH9.0 was performed before commencing with IHC staining protocol.
IHC shows positive staining in paraffin-embedded human tonsil. Anti-CD278/ICOS antibody was used at 1/500 dilution, Secondary antibody: #abs20040. Counterstained with hematoxylin. Heat mediated antigen retrieval with Tris/EDTA buffer pH9.0 was performed before commencing with IHC staining protocol.
Negative control: IHC shows negative staining in paraffin-embedded human kidney. Anti-CD278/ICOS antibody was used at 1/500 dilution, Secondary antibody: #abs20040. Counterstained with hematoxylin. Heat mediated antigen retrieval with Tris/EDTA buffer pH9.0 was performed before commencing with IHC staining protocol.
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