Rabbit anti-CD278/ICOS Recombinant Monoclonal Anti

简要描述：Rabbit anti-CD278/ICOS Recombinant Monoclonal Antibody(R104)，储存溶液：PBS, 40% Glycerol, 0.05% BSA, 0.03% Proclin 300

产品型号：abs171777
厂商性质：生产厂家
更新时间：2024-03-03
访问量：737

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详细介绍

品牌	absin	CAS	-
分子式	-	纯度	-
分子量	-	货号	abs171777
规格	100uL	供货周期	现货
主要用途	IHC-P: 1:500	应用领域	化工,生物产业,综合

概述
别名	Inducible T-cell costimulator; AILIM
宿主	Rabbit
反应种属	Human
应用	IHC-P: 1:500
性能
形式	Liquid
浓度	0.5 mg/ml
纯化方法	Protein A affinity column
类型	Monoclonal Antibody
克隆号	R104
储存/保存方法	Store at -20℃ for one year.
存储溶液	PBS, 40% Glycerol, 0.05% BSA, 0.03% Proclin 300
靶标
背景说明	Inducible T cell costimulatory factor (ICOS, cluster of differentiation, CD278) is an activated costimulatory immune checkpoint expressed on T cells. Its ligand ICOSL was expressed in antigen-presenting cells and somatic cells (including tumor cells in the tumor microenvironment) [PMID: 28713380, PMID: 12800259]. As one of the most common targeted immune checkpoints, ICOS is considered a possible way to develop new immunotherapy [PMID: 29544515]. Some clinical studies shown that blocking ICOS alone can inhibit tumor growth and proliferation, as well as TIGIT, CTLA4, and PD-1 [PMID: 30232519, PMID: 28803728].
细胞定位	Cell Membrane, Secreted
UniProt	Q9Y6W8
实验结果图
	IHC shows positive staining in paraffin-embedded human thymus. Anti-CD278/ICOS antibody was used at 1/500 dilution, Secondary antibody: #abs20040. Counterstained with hematoxylin. Heat mediated antigen retrieval with Tris/EDTA buffer pH9.0 was performed before commencing with IHC staining protocol.
	IHC shows positive staining in paraffin-embedded human tonsil. Anti-CD278/ICOS antibody was used at 1/500 dilution, Secondary antibody: #abs20040. Counterstained with hematoxylin. Heat mediated antigen retrieval with Tris/EDTA buffer pH9.0 was performed before commencing with IHC staining protocol.
	IHC shows positive staining in paraffin-embedded human tonsil. Anti-CD278/ICOS antibody was used at 1/500 dilution, Secondary antibody: #abs20040. Counterstained with hematoxylin. Heat mediated antigen retrieval with Tris/EDTA buffer pH9.0 was performed before commencing with IHC staining protocol.
	Negative control: IHC shows negative staining in paraffin-embedded human kidney. Anti-CD278/ICOS antibody was used at 1/500 dilution, Secondary antibody: #abs20040. Counterstained with hematoxylin. Heat mediated antigen retrieval with Tris/EDTA buffer pH9.0 was performed before commencing with IHC staining protocol.
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Rabbit anti-CD278/ICOS Recombinant Monoclonal Anti

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