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| 品牌 | absin | CAS | 761437-28-9 |
|---|---|---|---|
| 分子式 | C23H25ClN6O3 | 纯度 | ＞98% |
| 分子量 | 468.94 | 货号 | abs810514 |
| 规格 | 5mg | 供货周期 | 现货 |
| 主要用途 | is a potent FAK inhibitor with IC50 of 5 | 应用领域 | 化工,生物产业,农林牧渔,制药/生物制药,综合 |
TAE-226 761437-28-9
| 产品描述 | |
| 描述 | TAE226 (NVP-TAE226) is a potent FAK inhibitor with IC50 of 5.5 nM and modestly potent to Pyk2, ~10- to 100-fold less potent against InsR, IGF-1R, ALK, and c-Met. |
| 纯度 | >98% |
| 储存/保存方法 | Store at -20℃ for one year（Powder）；Store at 2-4℃ for two weeks；Store at -20℃ for six months after dissolution. |
| 基本信息 | |
| 别名 | TAE226, TAE-226,TAE 226,NVPTAE226 |
| 外观 | Powder |
| 可溶性/溶解性 | DMSO 94 mg/mL (200.45 mM) |
| 生物活性 | |
| 靶点 | PYK2 ,FAK ,Insulin Receptor ,IGF-1R ,c-Met |
| In vitro(体外研究) | NVP-TAE226 ( NVP-TAE226 (5 μM) inhibits phosphorylation of FAK in the human neuroblastoma cell line SK-N-AS. NVP-TAE226 ( NVP-TAE226 (0.1 μM-10 μM) inhibits tube formation of HMEC1 cells. |
| In vivo(体内研究) | NVP-TAE226 (75 mg/kg) significantly increases the survival rate of mice bearing intracranial glioma xenografts. NVP-TAE226 (100 mg/kg, oral) exerts significant decrease in microvessel density in a human colon cancer model in SCID mice. NVP-TAE226 (100 mg/kg, oral) efficiently inhibits MIA PaCa-2 human pancreatic tumor growth without body weight loss in vivo model. NVP-TAE226 inhibits 4T1 murine breast tumor growth and metastasis to the lung in a dose-dependent manner in vivo model, associated with inhibition of FAK autophosphorylation at Y397 and Akt phosphorylation at Serine473. |
| 研究领域 | |
| 研究领域 | CancerCancer MetabolismResponse to hypoxia MetabolismPathways and ProcessesMetabolism processesHypoxia Signal TransductionProtein PhosphorylationTyrosine KinasesFAK / PYK Signal TransductionProtein PhosphorylationTyrosine KinasesOther Drug DiscoverySmall Molecule DrugLead Compound Discovery |
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