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Product Category详细介绍
| 品牌 | absin | CAS | 94749-08-3 |
|---|---|---|---|
| 分子式 | C36H45NO7 | 纯度 | 98% |
| 分子量 | 603.75 | 货号 | abs47028321 |
| 规格 | 5mg | 供货周期 | 现货 |
| 主要用途 | used in the treatment of asthma symptoms | 应用领域 | 化工,生物产业,农林牧渔,制药/生物制药,综合 |
Salmeterol Xinafoate 94749-08-3
| 产品描述 | |
| 描述 | Salmeterol Xinafoate is a long-acting β2-adrenergic receptor agonist with anti-inflammatory effects, used in the treatment of asthma symptoms and chronic obstructive pulmonary disease (COPD) symptoms. |
| 纯度 | 98% |
| 储存/保存方法 | Store at -20℃ for one year（Powder）；Store at 2-4℃ for two weeks；Store at -20℃ for six months after dissolution. |
| 基本信息 | |
| 别名 | 昔美酸沙美特罗；沙美特罗昔萘酸酯；GR 33343X xinafoate |
| 外观 | 白色或类白色粉末 |
| 可溶性/溶解性 | DMSO : 60.4 mg/mL (100 mM) Ethanol : 12.1 mg/mL (20 mM) |
| 生物活性 | |
| 靶点 | Adrenergic Receptor |
| In vitro(体外研究) | Salmeterol significantly inhibits production of pro-inflammatory mediators by RAW264.7 and THP-1 cells. Salmeterol downregulates PgLPS-mediated phosphorylation of the ERK1/2 and JNK but not p38 MAP kinases (MAP-K). Salmeterol also attenuates the activation of NF-κB via inhibition of nuclear translocation of p65-NFκB, the transcriptional activity of NF-κB and IκBα phosphorylation. Salmeterol shows very high selectivity for the WT β2AR (β1 Ki /β2 Ki ratio of approximately 1500) with Ki of 1.5±0.4 nM. Salmeterol prevents phosphorylation levels of IRS-1Ser307 induced by tumor necrosis factor-α. Salmeterol alone prevents cell death in retinal Müller cells (p. Salmeterol (100 μM) causes apoptosis of DCs, and can not affect the differentiation and maturation of DCs at 10 μM. Salmeterol (10 μM) decreases the mRNA and protein levels of pro-inflammatory cytokines in LPS-activated DCs and inhibits MAPK and NF-κB activation. |
| In vivo(体内研究) | The OVA/LPS groups with salmeterol result in a significant decrease in the enhanced AHR in allergic mice in a dose-dependent manner. Salmeterol contends with asthma via regulating the inflammation of the airway of the mice. |
| 参考文献 | |
| 参考文献 |
| 研究领域 | |
| 研究领域 | Immunology NeuroscienceEndocrine system Drug DiscoverySmall Molecule DrugLead Compound Discovery |
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