SAR405838 1303607-60-4

简要描述：SAR405838 1303607-60-4
MI-77301 (SAR405838))is an orally available MDM2 antagonist with Ki of 0.88 nM. Phase 1.

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品牌	absin	CAS	1303607-60-4
分子式	C29H34Cl2FN3O3	纯度	98%
分子量	562.5	货号	abs47028298
规格	10mg	供货周期	现货
主要用途	is an orally available MDM2 antagonist	应用领域	化工,生物产业,农林牧渔,制药/生物制药,综合

SAR405838 1303607-60-4

产品描述
描述	MI-77301 (SAR405838))is an orally available MDM2 antagonist with Ki of 0.88 nM. Phase 1.
纯度	98%
储存/保存方法	Store at -20℃ for one year（Powder）；Store at 2-4℃ for two weeks；Store at -20℃ for six months after dissolution.
基本信息
别名	SAR405838
可溶性/溶解性	DMSO : 100 mg/mL (177.78 mM; Need ultrasonic)
生物活性
靶点	p53,MDM2
In vitro(体外研究)	MI-77301 (SAR405838) binds to MDM2 with Ki of 0.88 nM. MI-77301 (SAR405838) potently inhibits cell growth in cancer cell lines, including SJSA-1 (IC50, 0.092 μM), RS4;11 (IC50, 0.089 μM), LNCaP (IC50, 0.27 μM), and HCT-116 (IC50, 0.20 μM) cells, and displays high selectivity over cancer cell lines with mutated or deleted p53, including SAOS-2 (IC50, >10 μM), PC-3 (IC50, >10 μM), SW620 (IC50, >10 μM), and HCT-116 (p53-/-) (IC50, >20 μM) cells.
In vivo(体内研究)	In the SJSA-1 osteosarcoma, acute lymphoblastic leukemia RS4;11, LNCaP prostate cancer, and HCT-116 colon cancer xenograft model, MI-77301 (SAR405838) (p.o.) effectively inhibits tumor growth in a dose-dependent manner (10 mg/kg, 30 mg/kg, 50 mg/kg, 100 mg/kg, and 200 mg/kg,).
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研究领域

CancerCell cycleCell cycle inhibitorsp53 pathway

CancerOncoproteins/suppressorsTumor suppressorsp53 pathway

ApoptosisIntracellularp53 Pathway

Cell CycleCell Cycle Inhibitorsp53

EpigeneticsCell cycleCell Cycle Inhibitorsp53

EpigeneticsDNA / RNADNA Damage & RepairDNA Damage Responsep53

EpigeneticsTranscriptionCancer susceptibilityTumor Suppressors

NeuroscienceDevelopment

NeuroscienceProcesses

Drug DiscoverySmall Molecule DrugLead Compound Discovery

SAR405838 1303607-60-4温馨提示：本产品仅作科研实验使用，不支持临床等研究

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