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| 品牌 | absin | CAS | 301326-22-7 |
|---|---|---|---|
| 分子式 | C19H19N5O | 纯度 | ＞98% |
| 分子量 | 333.39 | 货号 | abs47028049 |
| 规格 | 5mg | 供货周期 | 现货 |
| 主要用途 | is a potent and specific aryl hydrocarbo | 应用领域 | 化工,生物产业,农林牧渔,制药/生物制药,综合 |
CH 223191 301326-22-7
| 产品描述 | |
| 描述 | CH 223191 is a potent and specific aryl hydrocarbon receptor (AhR) antagonist with IC50 of 30 nM. |
| 纯度 | ＞98% |
| 储存/保存方法 | Store at -20℃ for three years（Powder）；Store at 2-4℃ for two weeks；Store at -20℃ for six months after dissolution. |
| 基本信息 | |
| 别名 | CH-223191；CH223191 |
| 外观 | Yellow to orange powder |
| 可溶性/溶解性 | Ethanol ：3.3 mg/mL (10 mM) DMSO ：33.3 mg/mL (100 mM) |
| 生物活性 | |
| 靶点 | AhR |
| In vitro(体外研究) | CH-223191 blocks TCDD-mediated nuclear translocation and DNA binding of AhR, and also causes the inhibition of TCDD-induced cytochrome P450 enzyme activity. In human glioblastoma cells, CH-223191downregulates the TGF-beta/Smad pathway, and reduces clonogenic survival and invasiveness. In SK-N-SH human-derived neuronal cells, CH223191 counteracts the TCDD-induced suppression of neuronal acetylcholinesterase expression. In endothelial cells, CH-223191 potentiates ICAM-1 expression and prevents RelB nuclear translocation. |
| In vivo(体内研究) | CH-223191 (10 mg/kg/day, p.o.) potently prevents TCDD-caused cytochrome P450 induction, liver toxicity, and wasting syndrome in mice. |
| 研究领域 | |
| 研究领域 | EpigeneticsTranscriptionDomain FamiliesHLH / Leucine ZipperHelix-Turn-Helix NeuroscienceDevelopment NeuroscienceProcesses Drug DiscoverySmall Molecule DrugLead Compound Discovery |
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